Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 13/20 | 0.60 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5264179 | 0.93 | GPR119 (0.54) | GPR119MAPTSMN1; SMN2KDM4E | |
| SCHEMBL5264849 | 0.90 | GPR119 (0.52) | GPR119MAPTSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL1674011 | 0.89 | GPR119 (0.77) | GPR119MAPTMAPK1SMN1; SMN2KDM4E | |
| SCHEMBL5263835 | 0.88 | GPR119 (0.78) | GPR119MAPTMAPK1SMN1; SMN2KDM4E | |
| SCHEMBL5264529 | 0.85 | GPR119 (0.66) | GPR119MAPTSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL1673676 | 0.84 | GPR119 (0.55) | GPR119MAPTSMN1; SMN2ALDH1A1TSHR | |
| SCHEMBL5262427 | 0.82 | GPR119 (0.52) | GPR119MAPTSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL5261245 | 0.82 | GPR119 (0.54) | GPR119MAPTALDH1A1 | |
| SCHEMBL1673604 | 0.82 | GPR119 (0.69) | GPR119MAPTMAPK1KDM4EALDH1A1 | |
| SCHEMBL5263846 | 0.81 | GPR119 (0.61) | GPR119MAPTSMN1; SMN2KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1599468-B1 | 1,2,3-TRISUBSTITUTED ARYL AND HETEROARYL DERIVATIVES AS MODULATORS OF METABOLISM AND THE PROPHYLAXIS AND TREATMENT OF DISORDERS RELATED THERETO SUCH AS DIABETES AND HYPERGLYCEMIA | ARENA PHARM INC (US) | 2007-10-03 | — | — | EP | claimed |