Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 13/20 | 0.35 |
| ▸ | IDH1 | O75874 | 6/20 | 0.34 |
| ▸ | AURKA | O14965 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5264280 | 0.88 | MAPK14 (0.40) | MAPK14AURKA | |
| SCHEMBL5261120 | 0.87 | MAPK14 (0.38) | MAPK14AURKA | |
| SCHEMBL5914251 | 0.79 | BRD4 (0.38) | MAPK14 | |
| SCHEMBL5914249 | 0.79 | BRD4 (0.38) | MAPK14 | |
| SCHEMBL5914399 | 0.77 | MAPK14 (0.36) | MAPK14AURKA | |
| SCHEMBL5914118 | 0.76 | MAPK14 (0.42) | MAPK14AURKA | |
| SCHEMBL5914082 | 0.73 | MAPK14 (0.39) | MAPK14 | |
| SCHEMBL5314959 | 0.73 | MAPK14 (0.40) | MAPK14 | |
| SCHEMBL5914162 | 0.73 | HPGDS (0.40) | MAPK14IDH1 | |
| SCHEMBL5314967 | 0.73 | MAPK14 (0.40) | MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1794135-A1 | SUBSTITUTED HETEROCYCLIC COMPOUNDS AND METHODS OF USE | Amgen Inc. (US) | 2007-06-13 | — | — | EP | disclosed |
| WO-2006037117-A1 | SUBSTITUTED HETEROCYCLIC COMPOUNDS AND METHODS OF USE | AMGEN INC. (US) | 2006-04-06 | — | — | WO | disclosed |