Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.32 |
| ▸ | MAPT | P10636 | 3/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | HTT | P42858 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.31 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.31 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5262461 | 1.00 | KDM4E (0.32) | KDM4EMAPTMEN1LMNAHTT | |
| SCHEMBL5262467 | 1.00 | KDM4E (0.32) | KDM4EMAPTMEN1LMNAHTT | |
| SCHEMBL10212058 | 0.86 | KDM4E (0.36) | KDM4EMAPTMEN1LMNAHTT | |
| SCHEMBL5312857 | 0.81 | GABRA1 (0.31) | KDM4EMAPTMEN1LMNAHTT | |
| SCHEMBL426861 | 0.74 | SMYD3 (0.43) | GABRA1GABRB2 | |
| SCHEMBL429081 | 0.72 | GABRA1 (0.36) | KDM4EMAPTMEN1LMNAHTT | |
| SCHEMBL429057 | 0.71 | GABRA1 (0.36) | KDM4EMAPTMEN1LMNAHTT | |
| SCHEMBL429058 | 0.71 | GABRA1 (0.36) | KDM4EMAPTMEN1LMNAHTT | |
| SCHEMBL10212061 | 0.68 | KDM4E (0.37) | KDM4EMAPTMEN1LMNAHTT | |
| SCHEMBL7453500 | 0.66 | MAPT (0.35) | KDM4EMAPTMEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1786822-A1 | FUSED TRICYCLIC DERIVATIVES FOR THE TREATMENT OF PSYCHOTIC DISORDERS | GLAXO GROUP LIMITED (GB) | 2007-05-23 | — | — | EP | disclosed |
| WO-2006024517-A1 | FUSED TRICYCLIC DERIVATIVES FOR THE TREATMENT OF PSYCHOTIC DISORDERS | GLAXO GROUP LIMITED (GB) | 2006-03-09 | — | — | WO | disclosed |