Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 3/20 | 0.32 |
| ▸ | HCRTR2 | O43614 | 3/20 | 0.32 |
| ▸ | CCR4 | P51679 | 3/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | ALPL | P05186 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4511494 | 0.93 | HCRTR1 (0.34) | HCRTR1HCRTR2CCR4MAPT | |
| SCHEMBL5315816 | 0.84 | CCR4 (0.32) | HCRTR1HCRTR2CCR4ABCG2MAPT | |
| SCHEMBL4532654 | 0.84 | HCRTR1 (0.37) | HCRTR1HCRTR2GAAABCG2MAPT | |
| SCHEMBL5315372 | 0.84 | HCRTR1 (0.37) | HCRTR1HCRTR2GAAABCG2MAPT | |
| SCHEMBL4526388 | 0.81 | HCRTR1 (0.34) | HCRTR1HCRTR2MAPT | |
| SCHEMBL4526026 | 0.81 | HCRTR2 (0.35) | HCRTR1HCRTR2CCR4GAAALPL | |
| SCHEMBL4522897 | 0.80 | HCRTR1 (0.34) | HCRTR1HCRTR2CCR4MAPT | |
| SCHEMBL4511499 | 0.79 | HCRTR1 (0.33) | HCRTR1HCRTR2MAPT | |
| SCHEMBL4513370 | 0.70 | ABCG2 (0.36) | HCRTR1HCRTR2CCR4ABCG2 | |
| SCHEMBL4512965 | 0.68 | AXL (0.35) | HCRTR1HCRTR2CCR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1831216-A2 | HETEROAROMATIC DERIVATIVES USEFUL AS ANTICANCER AGENTS | Pfizer Products Inc. (US) | 2007-09-12 | — | — | EP | claimed |
| WO-2006067614-A2 | HETEROAROMATIC DERIVATIVES USEFUL AS ANTICANCER AGENTS | PFIZER PRODUCTS INC. (US) | 2006-06-29 | — | — | WO | claimed |
| EP-1831216-A2 | HETEROAROMATIC DERIVATIVES USEFUL AS ANTICANCER AGENTS | Pfizer Products Inc. (US) | 2007-09-12 | — | — | EP | disclosed |
| WO-2006067614-A2 | HETEROAROMATIC DERIVATIVES USEFUL AS ANTICANCER AGENTS | PFIZER PRODUCTS INC. (US) | 2006-06-29 | — | — | WO | disclosed |