Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 4/20 | 0.37 |
| ▸ | HCRTR2 | O43614 | 4/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 8/20 | 0.36 |
| ▸ | MEN1 | O00255 | 4/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.35 |
| ▸ | MAPT | P10636 | 4/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.35 |
| ▸ | NR2F2 | P24468 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 5/20 | 0.35 |
| ▸ | LMNA | P02545 | 4/20 | 0.35 |
| ▸ | PPP1CA | P62136 | 4/20 | 0.35 |
| ▸ | TSHR | P16473 | 4/20 | 0.35 |
| ▸ | XBP1 | P17861 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4532654 | 1.00 | HCRTR1 (0.37) | HCRTR1HCRTR2NPSR1MEN1KMT2A | |
| SCHEMBL4511494 | 0.91 | HCRTR1 (0.34) | HCRTR1HCRTR2NPSR1MEN1KMT2A | |
| SCHEMBL4526388 | 0.91 | HCRTR1 (0.34) | HCRTR1HCRTR2NPSR1MEN1KMT2A | |
| SCHEMBL4526026 | 0.91 | HCRTR2 (0.35) | HCRTR1HCRTR2NPSR1MEN1KMT2A | |
| SCHEMBL4522897 | 0.91 | HCRTR1 (0.34) | HCRTR1HCRTR2NPSR1MEN1KMT2A | |
| SCHEMBL4511499 | 0.85 | HCRTR1 (0.33) | HCRTR1HCRTR2NPSR1MEN1KMT2A | |
| SCHEMBL5262877 | 0.84 | HCRTR1 (0.32) | HCRTR1HCRTR2MAPTABCG2GAA | |
| SCHEMBL5315816 | 0.81 | CCR4 (0.32) | HCRTR1HCRTR2SMN1; SMN2KDM4EMAPT | |
| SCHEMBL4513370 | 0.78 | ABCG2 (0.36) | HCRTR1HCRTR2LTA4HABCG2 | |
| SCHEMBL4512965 | 0.72 | AXL (0.35) | HCRTR1HCRTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1831216-A2 | HETEROAROMATIC DERIVATIVES USEFUL AS ANTICANCER AGENTS | Pfizer Products Inc. (US) | 2007-09-12 | — | — | EP | disclosed |
| WO-2006067614-A2 | HETEROAROMATIC DERIVATIVES USEFUL AS ANTICANCER AGENTS | PFIZER PRODUCTS INC. (US) | 2006-06-29 | — | — | WO | disclosed |