Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | TOP2A | P11388 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | CES2 | O00748 | 1/20 | 0.44 |
| ▸ | CES1 | P23141 | 1/20 | 0.44 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.42 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 4/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.40 |
| ▸ | PLAU | P00749 | 1/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.40 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.40 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14646371 | 0.79 | MAPT (0.42) | LMNATOP2AKDM4EALDH1A1CES2 | |
| SCHEMBL9768928 | 0.75 | KDM4E (0.68) | LMNATOP2AKDM4EALDH1A1CES2 | |
| SCHEMBL17963025 | 0.75 | KDM4E (0.68) | LMNATOP2AKDM4EALDH1A1CES2 | |
| SCHEMBL25162057 | 0.75 | KDM4E (0.68) | LMNATOP2AKDM4EALDH1A1CES2 | |
| SCHEMBL31494657 | 0.75 | KDM4E (0.68) | LMNATOP2AKDM4EALDH1A1CES2 | |
| SCHEMBL5313208 | 0.74 | BAZ2B (0.46) | KDM4ENAPRTRAB9ASMN1; SMN2NPC1 | |
| SCHEMBL5313214 | 0.74 | BAZ2B (0.46) | KDM4ENAPRTRAB9ASMN1; SMN2NPC1 | |
| SCHEMBL12955737 | 0.74 | CES2 (0.52) | LMNAKDM4EALDH1A1CES2CES1 | |
| SCHEMBL30129831 | 0.74 | CES2 (0.52) | LMNAKDM4EALDH1A1CES2CES1 | |
| SCHEMBL18019541 | 0.74 | KMT2A (0.44) | LMNATOP2AKDM4EALDH1A1NAPRT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1781662-A1 | INHIBITORS OF HEPATITIS C VIRUS RNA-DEPENDENT RNA POLYMERASE, AND COMPOSITIONS AND TREATMENTS USING THE SAME | Pfizer, Inc. (US) | 2007-05-09 | — | — | EP | disclosed |
| WO-2006018725-A1 | INHIBITORS OF HEPATITIS C VIRUS RNA-DEPENDENT RNA POLYMERASE, AND COMPOSITIONS AND TREATMENTS USING THE SAME | PFIZER INC. (US) | 2006-02-23 | — | — | WO | disclosed |