Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | DOT1L | Q8TEK3 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.41 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.41 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | ULK1 | O75385 | 1/20 | 0.41 |
| ▸ | CES2 | O00748 | 1/20 | 0.41 |
| ▸ | CES1 | P23141 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4143751 | 0.81 | TAS1R3 (0.60) | PLK1GAAALDH1A1POLBTAS1R3 | |
| SCHEMBL883582 | 0.80 | POLB (0.69) | PLK1GAAALDH1A1POLBL3MBTL1 | |
| SCHEMBL30452120 | 0.80 | POLB (0.69) | PLK1GAAALDH1A1POLBL3MBTL1 | |
| SCHEMBL27944839 | 0.79 | PLK1 (0.50) | PLK1GAAALDH1A1POLBHDAC8 | |
| SCHEMBL10126900 | 0.79 | TAS1R3 (0.54) | PLK1GAAALDH1A1POLBL3MBTL1 | |
| SCHEMBL3780962 | 0.79 | DOT1L (0.50) | PLK1GAAALDH1A1POLBL3MBTL1 | |
| SCHEMBL5696499 | 0.79 | TSHR (0.45) | ALDH1A1POLBTAS1R3TAS1R1TAS1R2 | |
| SCHEMBL28784207 | 0.78 | TSHR (0.48) | ALDH1A1POLBTSHRCES2CES1 | |
| SCHEMBL3786271 | 0.78 | PLK1 (0.57) | PLK1GAAALDH1A1POLBL3MBTL1 | |
| SCHEMBL24311514 | 0.78 | GAA (0.56) | PLK1GAAALDH1A1POLBL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1817297-A1 | DIBENZYL AMINE COMPOUNDS AND DERIVATIVES | Pfizer Products Inc. (US) | 2007-08-15 | — | — | EP | disclosed |
| WO-2006056854-A1 | DIBENZYL AMINE COMPOUNDS AND DERIVATIVES | PFIZER PRODUCTS INC. (US) | 2006-06-01 | — | — | WO | disclosed |