Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 10/20 | 0.61 |
| ▸ | MAPT | P10636 | 5/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | BTK | Q06187 | 1/20 | 0.38 |
| ▸ | ACACB | O00763 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5263448 | 0.93 | GPR119 (0.61) | GPR119MAPTPOLBALDH1A1PDE10A | |
| SCHEMBL5263846 | 0.93 | GPR119 (0.61) | GPR119MAPTPOLBALDH1A1MEN1 | |
| SCHEMBL5264416 | 0.93 | GPR119 (0.60) | GPR119MAPTPOLBALDH1A1MEN1 | |
| SCHEMBL5262168 | 0.91 | GPR119 (0.64) | GPR119MAPTALDH1A1MEN1KMT2A | |
| SCHEMBL5261101 | 0.91 | GPR119 (0.68) | GPR119MAPTALDH1A1MEN1KMT2A | |
| SCHEMBL5264193 | 0.90 | GPR119 (0.63) | GPR119MAPTALDH1A1MEN1KMT2A | |
| SCHEMBL5266142 | 0.89 | GPR119 (0.60) | GPR119MAPTALDH1A1MEN1KMT2A | |
| SCHEMBL5264529 | 0.89 | GPR119 (0.66) | GPR119MAPTALDH1A1SMN1; SMN2ACACB | |
| SCHEMBL1673779 | 0.88 | GPR119 (0.78) | GPR119MAPTPOLBALDH1A1MEN1 | |
| SCHEMBL5263099 | 0.88 | GPR119 (0.65) | GPR119MAPTPOLBALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1599468-B1 | 1,2,3-TRISUBSTITUTED ARYL AND HETEROARYL DERIVATIVES AS MODULATORS OF METABOLISM AND THE PROPHYLAXIS AND TREATMENT OF DISORDERS RELATED THERETO SUCH AS DIABETES AND HYPERGLYCEMIA | ARENA PHARM INC (US) | 2007-10-03 | — | — | EP | claimed |