Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 19/20 | 0.79 |
| ▸ | CCND1 | P24385 | 18/20 | 0.79 |
| ▸ | CCND2 | P30279 | 17/20 | 0.79 |
| ▸ | CCND3 | P30281 | 17/20 | 0.79 |
| ▸ | CDK2 | P24941 | 11/20 | 0.79 |
| ▸ | CCNA2 | P20248 | 10/20 | 0.79 |
| ▸ | CCNA1 | P78396 | 8/20 | 0.79 |
| ▸ | CCNE2 | O96020 | 7/20 | 0.79 |
| ▸ | CCNE1 | P24864 | 7/20 | 0.79 |
| ▸ | CCNB2 | O95067 | 4/20 | 0.79 |
| ▸ | CDK1 | P06493 | 4/20 | 0.79 |
| ▸ | CCNB1 | P14635 | 4/20 | 0.79 |
| ▸ | CCNB3 | Q8WWL7 | 4/20 | 0.79 |
| ▸ | FGFR1 | P11362 | 7/20 | 0.71 |
| ▸ | FGFR2 | P21802 | 7/20 | 0.71 |
| ▸ | FGFR4 | P22455 | 7/20 | 0.71 |
| ▸ | FGFR3 | P22607 | 7/20 | 0.71 |
| ▸ | PAK4 | O96013 | 1/20 | 0.69 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.69 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10192614 | 0.89 | CDK4 (1.00) | CDK4CCND1CCND2CCND3CDK2 | |
| SCHEMBL5267901 | 0.88 | CDK4 (0.88) | CDK4CCND1CCND2CCND3CDK2 | |
| SCHEMBL5266345 | 0.87 | CDK4 (0.90) | CDK4CCND1CCND2CCND3CDK2 | |
| SCHEMBL3971770 | 0.87 | CDK4 (0.65) | CDK4CCND1CCND2CCND3CDK2 | |
| SCHEMBL5263290 | 0.86 | CDK4 (0.67) | CDK4CCND1CCND2CCND3CDK2 | |
| SCHEMBL5265792 | 0.85 | CDK4 (1.00) | CDK4CCND1CCND2CCND3CDK2 | |
| SCHEMBL4714586 | 0.85 | CDK4 (0.78) | CDK4CCND1CCND2CCND3CDK2 | |
| SCHEMBL5263902 | 0.85 | CDK4 (1.00) | CDK4CCND1CCND2CCND3CDK2 | |
| SCHEMBL5263022 | 0.85 | CDK4 (1.00) | CDK4CCND1CCND2CCND3CDK2 | |
| SCHEMBL5266784 | 0.85 | CDK4 (1.00) | CDK4CCND1CCND2CCND3CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1806348-A2 | Pyrido (2,3-D)Pyrimidines as inhibitors of cellular proliferation | Warner-Lambert Company LLC (US) | 2007-07-11 | — | — | EP | disclosed |
| US-6498163-B1 | POTENT INHIBITORS OF CYCLIN-DEPENDENT KINASES AND GROWTH FACTOR MEDIATED KINASES; CANCER, RESTENOSIS, ATHEROSCLEROSIS | WARNER-LAMBERT COMPANY | 2002-12-24 | — | — | US | disclosed |
| EP-1255755-A1 | PYRIDOPYRIMIDINONE DERIVATIVES FOR TREATMENT OF NEURODEGENERATIVE DISEASE | WARNER-LAMBERT COMPANY (US) | 2002-11-13 | — | — | EP | disclosed |
| WO-2001055148-A1 | PYRIDOPYRIMIDINONE DERIVATIVES FOR TREATMENT OF NEURODEGENERATIVE DISEASE | WARNER-LAMBERT COMPANY (US) | 2001-08-02 | — | — | WO | disclosed |