Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP30 | Q70CQ3 | 5/20 | 0.44 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HPGDS | O60760 | 1/20 | 0.39 |
| ▸ | CKS1B | P61024 | 1/20 | 0.39 |
| ▸ | SKP1 | P63208 | 1/20 | 0.39 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.39 |
| ▸ | BTK | Q06187 | 2/20 | 0.38 |
| ▸ | IDH1 | O75874 | 1/20 | 0.38 |
| ▸ | IDH2 | P48735 | 1/20 | 0.38 |
| ▸ | JUN | P05412 | 1/20 | 0.38 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.38 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.38 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5341690 | 0.80 | USP30 (0.48) | USP30PRMT5MAPK14ADORA2AALDH1A1 | |
| SCHEMBL5914088 | 0.78 | USP30 (0.46) | USP30PRMT5MAPK14ADORA2AALDH1A1 | |
| SCHEMBL5913836 | 0.77 | ALDH1A1 (0.48) | USP30MAPK14ADORA2AALDH1A1IDH1 | |
| SCHEMBL5948116 | 0.76 | USP30 (0.44) | USP30PRMT5MAPK14ADORA2AHPGDS | |
| SCHEMBL6420529 | 0.76 | USP30 (0.45) | USP30PRMT5MAPK14ADORA2AALDH1A1 | |
| SCHEMBL3775260 | 0.73 | USP30 (0.67) | USP30ALDH1A1HPGDSCKS1BSKP1 | |
| SCHEMBL5913810 | 0.72 | MAPK8 (0.48) | USP30MAPK14ALDH1A1CKS1BSKP1 | |
| SCHEMBL14190733 | 0.72 | ALDH1A1 (0.55) | USP30ADORA2AALDH1A1IDH1IDH2 | |
| SCHEMBL12367077 | 0.72 | ALDH1A1 (0.55) | USP30ADORA2AALDH1A1BTKIDH1 | |
| SCHEMBL3650816 | 0.72 | HDAC8 (0.52) | USP30PRMT5ADORA2AALDH1A1IDH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1794135-A1 | SUBSTITUTED HETEROCYCLIC COMPOUNDS AND METHODS OF USE | Amgen Inc. (US) | 2007-06-13 | — | — | EP | disclosed |
| WO-2006037117-A1 | SUBSTITUTED HETEROCYCLIC COMPOUNDS AND METHODS OF USE | AMGEN INC. (US) | 2006-04-06 | — | — | WO | disclosed |