Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 10/20 | 0.54 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.49 |
| ▸ | EGFR | P00533 | 1/20 | 0.49 |
| ▸ | KDR | P35968 | 2/20 | 0.48 |
| ▸ | TEK | Q02763 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.44 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.44 |
| ▸ | CSF1R | P07333 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1265258 | 0.88 | TEK (0.66) | BRAFMAPK14EGFRKDRTEK | |
| SCHEMBL1265444 | 0.78 | TEK (0.81) | BRAFMAPK14KDRTEK | |
| SCHEMBL1265113 | 0.75 | TEK (0.70) | BRAFMAPK14KDRTEK | |
| Acetic Acid SCHEMBL2684357 | 0.74 | TRPV1 (0.60) | BRAFNPC1RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL1264685 | 0.73 | TEK (0.81) | BRAFMAPK14KDRTEK | |
| SCHEMBL1264350 | 0.71 | KDR (0.67) | BRAFMAPK14KDRTEKSMN1; SMN2 | |
| SCHEMBL30132679 | 0.71 | MAPT (0.57) | NPC1RAB9AMEN1KMT2AALDH1A1 | |
| SCHEMBL2963586 | 0.70 | CSF1R (0.57) | BRAFMAPK14EGFRNPC1RAB9A | |
| SCHEMBL1265486 | 0.70 | BRAF (0.67) | BRAFMAPK14KDRTEK | |
| SCHEMBL1264803 | 0.70 | TEK (0.77) | BRAFMAPK14KDRTEK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1751136-A2 | NITROGENATED HETEROCYCLIC DERIVATIVES AS PROTEIN KINASE MODULATORS AND USE FOR THE TREATMENT OF ANGIOGENESIS AND CANCER | AMGEN INC. (US) | 2007-02-14 | — | — | EP | disclosed |
| WO-2005113494-A2 | NITROGENATED HETEROCYCLIC DERIVATIVES AS PROTEIN KINASE MODULATORS AND USE FOR THE TREATMENT OF ANGIOGENESIS AND CANCER | AMGEN INC. (US) | 2005-12-01 | — | — | WO | disclosed |