Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 17/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.36 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.35 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | PDE1A | P54750 | 1/20 | 0.34 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.34 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5264617 | 0.94 | PDE5A (0.40) | PDE5AADORA2AADORA2B | |
| SCHEMBL5260943 | 0.92 | PDE5A (0.41) | PDE5AADORA2AADORA2BPDE3BPDE3A | |
| SCHEMBL5831150 | 0.88 | PDE5A (0.57) | PDE5APDE3BPDE3APDE1APDE1B | |
| SCHEMBL5263574 | 0.87 | PDE5A (0.41) | PDE5AADORA2AADORA2BKMT2AKDM4E | |
| SCHEMBL5259938 | 0.87 | PDE5A (0.49) | PDE5APDE3BPDE3APDE1APDE1B | |
| SCHEMBL5830264 | 0.86 | PDE5A (0.51) | PDE5APDE3BPDE3APDE1APDE1B | |
| SCHEMBL5261815 | 0.86 | PDE5A (0.40) | PDE5AADORA2AADORA2B | |
| SCHEMBL5260459 | 0.85 | PDE5A (0.39) | PDE5A | |
| SCHEMBL5260344 | 0.85 | PDE5A (0.44) | PDE5AADORA2AADORA2B | |
| SCHEMBL6305122 | 0.85 | PDE5A (0.52) | PDE5AADORA2AADORA2BPDE3BPDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1307458-B1 | PYRROLOTRIAZOLOPYRIMIDINONE DERIVATIVES | ALMIRALL LAB (ES) | 2007-10-03 | — | — | EP | disclosed |
| US-7060824-B2 | Pyrrolotriazolopyrimidinone derivatives | ALMIRALL PRODESFARMA, S.A. (ES) | 2006-06-13 | — | — | US | disclosed |