Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | LTB4R | Q15722 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 3/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.32 |
| ▸ | HMGCR | P04035 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | CNR2 | P34972 | 3/20 | 0.31 |
| ▸ | CNR1 | P21554 | 2/20 | 0.31 |
| ▸ | NR1H4 | Q96RI1 | 3/20 | 0.31 |
| ▸ | HTR2A | P28223 | 2/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4470445 | 0.81 | HTT (0.38) | HTTLTB4RMEN1KMT2A | |
| SCHEMBL6414827 | 0.80 | MEN1 (0.36) | MEN1KMT2AALDH1A1CYP3A4CYP2D6 | |
| SCHEMBL6218165 | 0.71 | KMT2A (0.39) | MEN1KMT2AALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL48212 | 0.69 | HTT (0.64) | HTTLTB4RMEN1KMT2AHMGCR | |
| SCHEMBL3988344 | 0.67 | HMGCR (0.32) | HMGCRCNR2CNR1HTR2A | |
| SCHEMBL47985 | 0.66 | HTT (0.58) | HTTLTB4RMEN1KMT2AHMGCR | |
| SCHEMBL29220972 | 0.65 | HTT (0.66) | HTTLTB4RMEN1KMT2AHMGCR | |
| SCHEMBL30818285 | 0.65 | HTT (0.66) | HTTLTB4RMEN1KMT2AHMGCR | |
| SCHEMBL13596107 | 0.65 | HTT (0.66) | HTTMEN1KMT2AHMGCRALDH1A1 | |
| SCHEMBL3959266 | 0.65 | HTT (0.60) | HTTMEN1KMT2AHMGCRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1781662-A1 | INHIBITORS OF HEPATITIS C VIRUS RNA-DEPENDENT RNA POLYMERASE, AND COMPOSITIONS AND TREATMENTS USING THE SAME | Pfizer, Inc. (US) | 2007-05-09 | — | — | EP | disclosed |
| WO-2006018725-A1 | INHIBITORS OF HEPATITIS C VIRUS RNA-DEPENDENT RNA POLYMERASE, AND COMPOSITIONS AND TREATMENTS USING THE SAME | PFIZER INC. (US) | 2006-02-23 | — | — | WO | disclosed |