Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.66 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.49 |
| ▸ | HPGD | P15428 | 3/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | HMGCR | P04035 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | PRKCE | Q02156 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | TTR | P02766 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | RECQL | P46063 | 3/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13596109 | 0.86 | CYP3A4 (0.50) | HTTCYP3A4HPGDMAPK1ALDH1A1 | |
| SCHEMBL29220972 | 0.83 | HTT (0.66) | HTTCYP3A4HPGDMAPK1ALDH1A1 | |
| SCHEMBL30818285 | 0.83 | HTT (0.66) | HTTCYP3A4HPGDMAPK1ALDH1A1 | |
| SCHEMBL28652985 | 0.82 | HTT (0.55) | HTTCYP3A4HPGDMAPK1ALDH1A1 | |
| SCHEMBL48212 | 0.82 | HTT (0.64) | HTTCYP3A4HPGDMAPK1ALDH1A1 | |
| SCHEMBL13596108 | 0.81 | HTT (0.41) | HTTCYP3A4MAPK1ALDH1A1HMGCR | |
| SCHEMBL30398255 | 0.80 | HTT (1.00) | HTTCYP3A4HPGDMAPK1ALDH1A1 | |
| SCHEMBL3661837 | 0.80 | HTT (1.00) | HTTCYP3A4HPGDMAPK1ALDH1A1 | |
| SCHEMBL3959266 | 0.80 | HTT (0.60) | HTTCYP3A4HPGDALDH1A1HMGCR | |
| SCHEMBL3957202 | 0.80 | HTT (0.69) | HTTCYP3A4HPGDHMGCRMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090318690-A1 | Benzisoxazole Compound | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2009-12-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090318690-A1 | Benzisoxazole Compound | NR1I2, NR1I3, NR0B1 | HTT 3905/4885CYP3A4 157/4885HPGD 3421/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.