Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 20/20 | 0.66 |
| ▸ | MMP2 | P08253 | 2/20 | 0.59 |
| ▸ | MMP10 | P09238 | 2/20 | 0.59 |
| ▸ | MMP8 | P22894 | 2/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4932669 | 0.91 | MMP13 (0.78) | MMP13MMP2MMP10MMP8 | |
| SCHEMBL4934626 | 0.90 | MMP13 (0.71) | MMP13 | |
| SCHEMBL689429 | 0.81 | MMP13 (0.80) | MMP13MMP2MMP10MMP8 | |
| SCHEMBL4934689 | 0.81 | MMP13 (0.84) | MMP13 | |
| SCHEMBL4936762 | 0.81 | MMP13 (0.67) | MMP13MMP2MMP10MMP8 | |
| SCHEMBL4934211 | 0.81 | MMP13 (0.84) | MMP13 | |
| SCHEMBL3641284 | 0.81 | MMP13 (0.86) | MMP13 | |
| SCHEMBL16562162 | 0.81 | BRD4 (0.61) | MMP13 | |
| SCHEMBL8279679 | 0.80 | MMP13 (0.73) | MMP13MMP2MMP10MMP8 | |
| SCHEMBL688369 | 0.80 | MMP13 (1.00) | MMP13MMP2MMP10MMP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1740551-A1 | HETEROCYCLIC AMIDE COMPOUND AND USE THEREOF AS AN MMP-13 INHIBITOR | Takeda Pharmaceutical Company Limited (JP) | 2007-01-10 | — | — | EP | disclosed |
| WO-2005105760-A1 | HETEROCYCLIC AMIDE COMPOUND AND USE THEREOF AS AN MMP-13 INHIBITOR | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2005-11-10 | — | — | WO | disclosed |