⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL754334 | 0.81 | TDP1 (0.31) | — | |
| SCHEMBL1670 | 0.81 | — | — | |
| SCHEMBL9397770 | 0.78 | — | — | |
| SCHEMBL28871555 | 0.75 | — | — | |
| SCHEMBL8751772 | 0.70 | — | — | |
| Methylamine SCHEMBL18979545 | 0.65 | — | — | |
| SCHEMBL15767062 | 0.63 | — | — | |
| SCHEMBL2153342 | 0.63 | — | — | |
| SCHEMBL2185750 | 0.63 | — | — | |
| SCHEMBL3035585 | 0.61 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1761540-A1 | QUINAZOLINONES AS INHIBITORS OF HUMAN PHOSPHATIDYLINOSITOL 3-KINASE DELTA | ICOS CORPORATION (US) | 2007-03-14 | — | — | EP | disclosed |
| WO-2005113556-A1 | QUINAZOLINONES AS INHIBITORS OF HUMAN PHOSPHATIDYLINOSITOL 3-KINASE DELTA | ICOS CORPORATION (US) | 2005-12-01 | — | — | WO | disclosed |
| US-6579967-B1 | Cyclic peptide of given amino acid sequence; improves binding strength by adding a carbamoyl moiety at N-terminus; useful in determining tissue/cellular expression and in drug screening | THE SALK INSTITUTE FOR BIOLOGICAL STUDIES | 2003-06-17 | — | — | US | disclosed |
| EP-1294691-A1 | SERINE PROTEASE INHIBITORS | Tularik Limited (GB) | 2003-03-26 | — | — | EP | disclosed |
| WO-2001096305-A1 | SERINE PROTEASE INHIBITORS | TULARIK LIMITED (GB) | 2001-12-20 | — | — | WO | disclosed |
| WO-2001014346-A1 | MACROCYCLIC COMPOUNDS AND PREPARATION METHODS THEREOF | ISIS PHARMACEUTICALS, INC. (US) | 2001-03-01 | — | — | WO | disclosed |
| EP-0927192-A1 | MODIFIED AMINOACIDS, PHARMACEUTICALS CONTAINING THESE COMPOUNDS AND METHOD FOR THEIR PRODUCTION | Dr. Karl Thomae GmbH (DE) | 1999-07-07 | — | — | EP | disclosed |
| WO-1998011128-A1 | MODIFIED AMINOACIDS, PHARMACEUTICALS CONTAINING THESE COMPOUNDS AND METHOD FOR THEIR PRODUCTION | DR. KARL THOMAE GMBH (DE) | 1998-03-19 | — | — | WO | disclosed |
| US-5516786-A | Fungicidal substituted amino acid amides | BAYER AKTIENGESELLSCHAFT (DE) | 1996-05-14 | — | — | US | disclosed |
| US-5504109-A | PESTICIDES | BAYER AKTIENGESELLSCHAFT (DE) | 1996-04-02 | — | — | US | disclosed |
| US-5486596-A | CYCLIC PEPTIDES | CESKOSLOVENSKA AKADEMIE VED (CS) | 1996-01-23 | — | — | US | disclosed |
| US-5411987-A | Fungicidal substituted amino acid amides | BAYER AKTIENGESELLSCHAFT (DE) | 1995-05-02 | — | — | US | disclosed |
| US-5210084-A | Amidoalkylcarbamates | BAYER AKTIENGESELLSCHAFT (DE) | 1993-05-11 | — | — | US | disclosed |