Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 8/20 | 0.59 |
| ▸ | RAF1 | P04049 | 1/20 | 0.53 |
| ▸ | YES1 | P07947 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | MAPK14 | Q16539 | 8/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20133847 | 0.82 | BRAF (0.69) | BRAFRAF1YES1KDM4EALDH1A1 | |
| SCHEMBL4166506 | 0.81 | BRAF (0.64) | BRAFRAF1YES1KDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL15939103 | 0.80 | BRAF (0.63) | BRAFRAF1YES1KDM4EALDH1A1 | |
| SCHEMBL4164155 | 0.79 | BRAF (0.65) | BRAFRAF1YES1KDM4EALDH1A1 | |
| SCHEMBL4244844 | 0.78 | BRAF (0.61) | BRAFRAF1YES1KDM4EALDH1A1 | |
| SCHEMBL15939192 | 0.77 | BRAF (0.60) | BRAFRAF1YES1KDM4EALDH1A1 | |
| SCHEMBL20602470 | 0.74 | L3MBTL1 (0.48) | BRAFKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL23497849 | 0.74 | BRAF (0.67) | BRAFRAF1YES1KDM4EALDH1A1 | |
| SCHEMBL12499415 | 0.74 | BRAF (1.00) | BRAFRAF1YES1KDM4EALDH1A1 | |
| SCHEMBL23517114 | 0.74 | KDM4E (0.68) | BRAFRAF1YES1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1789399-A1 | QUINAZOLINONE DERIVATIVES AND THEIR USE AS B-RAF INHIBITORS | AstraZeneca AB (SE) | 2007-05-30 | — | — | EP | disclosed |
| WO-2006024834-A1 | QUINAZOLINONE DERIVATIVES AND THEIR USE AS B-RAF INHIBITORS | ASTRAZENECA AB (SE) | 2006-03-09 | — | — | WO | disclosed |