Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 15/20 | 0.57 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | ERBB3 | P21860 | 1/20 | 0.43 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5263545 | 0.92 | GPR119 (0.57) | GPR119 | |
| SCHEMBL5264420 | 0.90 | GPR119 (0.57) | GPR119 | |
| SCHEMBL389009 | 0.90 | GPR119 (0.70) | GPR119LIMK2MEN1KMT2A | |
| SCHEMBL5262778 | 0.89 | GPR119 (0.52) | GPR119 | |
| SCHEMBL5264895 | 0.86 | GPR119 (0.55) | GPR119 | |
| SCHEMBL5260172 | 0.86 | GPR119 (0.65) | GPR119 | |
| SCHEMBL5263642 | 0.85 | GPR119 (0.54) | GPR119MEN1KMT2A | |
| SCHEMBL5265329 | 0.85 | GPR119 (0.57) | GPR119 | |
| SCHEMBL5264940 | 0.85 | GPR119 (0.64) | GPR119 | |
| SCHEMBL5263198 | 0.85 | GPR119 (0.57) | GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1599468-B1 | 1,2,3-TRISUBSTITUTED ARYL AND HETEROARYL DERIVATIVES AS MODULATORS OF METABOLISM AND THE PROPHYLAXIS AND TREATMENT OF DISORDERS RELATED THERETO SUCH AS DIABETES AND HYPERGLYCEMIA | ARENA PHARM INC (US) | 2007-10-03 | — | — | EP | claimed |