Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 2/20 | 0.57 |
| ▸ | CA2 | P00918 | 2/20 | 0.57 |
| ▸ | MMP1 | P03956 | 1/20 | 0.57 |
| ▸ | MMP2 | P08253 | 1/20 | 0.57 |
| ▸ | MMP9 | P14780 | 1/20 | 0.57 |
| ▸ | MMP8 | P22894 | 1/20 | 0.57 |
| ▸ | MMP13 | P45452 | 1/20 | 0.57 |
| ▸ | FAAH | O00519 | 1/20 | 0.52 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.52 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.52 |
| ▸ | ELANE | P08246 | 1/20 | 0.52 |
| ▸ | PRTN3 | P24158 | 1/20 | 0.52 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | CA5A | P35218 | 1/20 | 0.47 |
| ▸ | CA9 | Q16790 | 1/20 | 0.47 |
| ▸ | PGR | P06401 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | AR | P10275 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL634086 | 0.80 | CA1 (0.57) | CA1CA2MMP1MMP2MMP9 | |
| SCHEMBL9006011 | 0.79 | CA1 (0.65) | CA1CA2MMP1MMP2MMP9 | |
| SCHEMBL4301369 | 0.77 | CA1 (0.53) | CA1CA2MMP1MMP2MMP9 | |
| SCHEMBL6492175 | 0.76 | CA1 (0.68) | CA1CA2MMP1MMP2MMP9 | |
| SCHEMBL2462098 | 0.76 | CA1 (0.56) | CA1CA2MMP1MMP2MMP9 | |
| SCHEMBL14675961 | 0.74 | CA1 (0.55) | CA1CA2MMP1MMP2MMP9 | |
| SCHEMBL5963267 | 0.74 | CA1 (0.55) | CA1CA2MMP1MMP2MMP9 | |
| SCHEMBL5899466 | 0.74 | CA1 (0.50) | CA1CA2MMP1MMP2MMP9 | |
| SCHEMBL2322534 | 0.74 | PRSS1 (0.67) | CA1CA2MMP1MMP2MMP9 | |
| SCHEMBL21763639 | 0.74 | CA1 (0.65) | CA1CA2MMP1MMP2MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4313308-A1 | TEAD INHIBITORS AND USES THEREOF | Cedilla Therapeutics, Inc. (US) | 2024-02-07 | — | — | EP | disclosed |
| WO-2022204452-A1 | TEAD INHIBITORS AND USES THEREOF | CEDILLA THERAPEUTICS, INC. (US) | 2022-09-29 | — | — | WO | disclosed |
| CN-113045550-A | Triazole derivative and preparation method and application thereof | 深圳济康医药科技有限公司 | 2021-06-29 | — | — | CN | disclosed |
| CN-112538069-A | Azole derivative or pharmaceutically acceptable salt thereof, and preparation method and application thereof | 苏州艾和医药科技有限公司 | 2021-03-23 | — | — | CN | disclosed |
| EP-1737858-A1 | SULFONAMIDES | MERCK PATENT GmbH (DE) | 2007-01-03 | — | — | EP | disclosed |
| WO-2005105797-A1 | SULFONAMIDES | MERCK PATENT GMBH (DE) | 2005-11-10 | — | — | WO | disclosed |