Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.53 |
| ▸ | AR | P10275 | 2/20 | 0.51 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.46 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9926054 | 1.00 | LMNA (0.53) | LMNANPSR1ARTHRBPOLB | |
| SCHEMBL9926126 | 0.87 | SMN1; SMN2 (0.48) | ARTHRBPOLBSMN1; SMN2HTT | |
| SCHEMBL4849287 | 0.87 | SMN1; SMN2 (0.53) | LMNAARTHRBPOLBSMN1; SMN2 | |
| SCHEMBL4840571 | 0.87 | SMN1; SMN2 (0.53) | LMNAARTHRBPOLBSMN1; SMN2 | |
| SCHEMBL4848729 | 0.87 | SMN1; SMN2 (0.53) | LMNAARTHRBPOLBSMN1; SMN2 | |
| SCHEMBL4851095 | 0.87 | SMN1; SMN2 (0.53) | LMNAARTHRBPOLBSMN1; SMN2 | |
| SCHEMBL4849420 | 0.87 | SMN1; SMN2 (0.53) | LMNAARTHRBPOLBSMN1; SMN2 | |
| SCHEMBL9926064 | 0.86 | SMN1; SMN2 (0.53) | LMNANPSR1ARPOLBSMN1; SMN2 | |
| SCHEMBL4840287 | 0.86 | MC4R (0.54) | LMNATHRBPOLBSMN1; SMN2HTT | |
| SCHEMBL9926053 | 0.86 | MC4R (0.54) | LMNATHRBPOLBSMN1; SMN2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1836180-A2 | SULFONYL PYRROLIDINES, METHOD FOR PRODUCING THE SAME AND THEIR USE AS DRUGS | sanofi-aventis (FR) | 2007-09-26 | — | — | EP | disclosed |
| WO-2006072393-A2 | SULFONYL PYRROLIDINES, METHOD FOR PRODUCING THE SAME AND THEIR USE AS DRUGS | SANOFI-AVENTIS (DE) | 2006-07-13 | — | — | WO | disclosed |