Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACACB | O00763 | 8/20 | 0.44 |
| ▸ | ACACA | Q13085 | 5/20 | 0.44 |
| ▸ | LATS1 | O95835 | 3/20 | 0.44 |
| ▸ | LATS2 | Q9NRM7 | 1/20 | 0.44 |
| ▸ | CKS1B | P61024 | 2/20 | 0.44 |
| ▸ | SKP1 | P63208 | 2/20 | 0.44 |
| ▸ | SKP2 | Q13309 | 2/20 | 0.44 |
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
| ▸ | AURKA | O14965 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.35 |
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5914046 | 0.89 | AURKA (0.39) | ACACBACACAAURKAUSP2ALDH1A1 | |
| SCHEMBL5267139 | 0.82 | ACACB (0.41) | ACACBACACALATS1LATS2CKS1B | |
| SCHEMBL5914334 | 0.79 | AURKA (0.38) | AURKAUSP2ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL5913810 | 0.79 | MAPK8 (0.48) | ACACBACACACKS1BSKP1SKP2 | |
| SCHEMBL5914408 | 0.78 | CYP1A2 (0.40) | AURKAUSP2ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL5264552 | 0.78 | CYP1A2 (0.43) | ACACBACACAAURKAUSP2ALDH1A1 | |
| SCHEMBL5914098 | 0.78 | MAPK14 (0.39) | ACACBACACACKS1BSKP1SKP2 | |
| SCHEMBL5914093 | 0.78 | MAPK14 (0.39) | ACACBACACACKS1BSKP1SKP2 | |
| SCHEMBL5264843 | 0.76 | MAPK14 (0.41) | CKS1BSKP1SKP2AURKAUSP2 | |
| SCHEMBL5914331 | 0.74 | AURKA (0.38) | AURKAUSP2ALDH1A1CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1794135-A1 | SUBSTITUTED HETEROCYCLIC COMPOUNDS AND METHODS OF USE | Amgen Inc. (US) | 2007-06-13 | — | — | EP | disclosed |
| WO-2006037117-A1 | SUBSTITUTED HETEROCYCLIC COMPOUNDS AND METHODS OF USE | AMGEN INC. (US) | 2006-04-06 | — | — | WO | disclosed |
| US-20060069110-A1 | Substituted heterocyclic compounds and methods of use | AMGEN INC. | 2006-03-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060069110-A1 | Substituted heterocyclic compounds and methods of use | MAPT, MYLK2, IAPP | ACACB 2217/4885ACACA 2863/4885LATS1 1842/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.