Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 6/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.35 |
| ▸ | KDR | P35968 | 4/20 | 0.34 |
| ▸ | TP53 | P04637 | 2/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5914046 | 0.83 | AURKA (0.39) | AURKACYP1A2CYP3A4ALDH1A1CYP2D6 | |
| SCHEMBL5914408 | 0.81 | CYP1A2 (0.40) | AURKACYP1A2CYP3A4ALDH1A1CYP2D6 | |
| SCHEMBL5264835 | 0.79 | ACACB (0.44) | AURKACYP1A2CYP3A4ALDH1A1CYP2D6 | |
| SCHEMBL5264552 | 0.78 | CYP1A2 (0.43) | AURKACYP1A2CYP3A4ALDH1A1CYP2D6 | |
| SCHEMBL5914053 | 0.75 | MAPK14 (0.44) | AURKAMAPK14 | |
| SCHEMBL5914331 | 0.75 | AURKA (0.38) | AURKACYP1A2CYP3A4ALDH1A1CYP2D6 | |
| SCHEMBL5913876 | 0.73 | TAAR1 (0.46) | AURKACYP1A2CYP3A4ALDH1A1CYP2D6 | |
| SCHEMBL5913896 | 0.73 | TAAR1 (0.46) | AURKACYP1A2CYP3A4ALDH1A1CYP2D6 | |
| SCHEMBL5261647 | 0.72 | NPR3 (0.47) | AURKACYP1A2CYP3A4ALDH1A1CYP2D6 | |
| SCHEMBL5913860 | 0.72 | NPR3 (0.47) | AURKACYP1A2CYP3A4ALDH1A1CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060069110-A1 | Substituted heterocyclic compounds and methods of use | AMGEN INC. | 2006-03-30 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060069110-A1 | Substituted heterocyclic compounds and methods of use | MAPT, MYLK2, IAPP | AURKA 2082/4885CYP1A2 1159/4885CYP3A4 1290/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.