Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.57 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | PKM | P14618 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | NPY1R | P25929 | 1/20 | 0.46 |
| ▸ | NPY2R | P49146 | 1/20 | 0.46 |
| ▸ | PARP1 | P09874 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | PDE4A | P27815 | 1/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5264870 | 1.00 | MAPT (0.57) | MAPTMEN1KMT2AALDH1A1PKM | |
| SCHEMBL3878412 | 0.89 | PARP1 (0.53) | MAPTMEN1KMT2AALDH1A1PKM | |
| SCHEMBL3878261 | 0.83 | AR (0.55) | MAPTMEN1KMT2AALDH1A1HPGD | |
| SCHEMBL18322288 | 0.82 | MAP2 (0.53) | MEN1KMT2AALDH1A1PARP1KDM4E | |
| SCHEMBL29030308 | 0.82 | PDE9A (0.56) | MEN1KMT2AALDH1A1KDM4EHPGD | |
| SCHEMBL3944802 | 0.73 | MAPT (1.00) | MAPTMEN1KMT2AALDH1A1PKM | |
| SCHEMBL4035321 | 0.71 | MAPT (0.49) | MAPTMEN1KMT2AALDH1A1PKM | |
| SCHEMBL3877998 | 0.71 | PARP1 (0.48) | PARP1MAPK14 | |
| SCHEMBL22907746 | 0.70 | MAP2 (0.53) | MAPTPOLBPARP1PDE4AMAPK14 | |
| SCHEMBL27791164 | 0.70 | DHODH (0.50) | ALDH1A1PARP1KDM4EHPGDMAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101098868-A | Substituted indoles, compositions containing them, method for the production thereof and their use | AVENTIS PHARMA SA (FR) | 2008-01-02 | — | — | CN | disclosed |
| EP-1841762-A1 | SUBSTITUTED INDOLES, COMPOSITIONS CONTAINING THEM, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE | Aventis Pharma S.A. (FR) | 2007-10-10 | — | — | EP | disclosed |
| WO-2006061493-A1 | SUBSTITUTED INDOLES, COMPOSITIONS CONTAINING THEM, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE | AVENTIS PHARMA S.A. (FR) | 2006-06-15 | — | — | WO | disclosed |