Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE9A | O76083 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.53 |
| ▸ | HPGD | P15428 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | GFER | P55789 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | TGFBR1 | P36897 | 3/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.42 |
| ▸ | MAP2 | P11137 | 1/20 | 0.41 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | ADK | P55263 | 1/20 | 0.40 |
| ▸ | GPR35 | Q9HC97 | 3/20 | 0.40 |
| ▸ | COMT | P21964 | 1/20 | 0.40 |
| ▸ | RPA1 | P27694 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18322288 | 0.86 | MAP2 (0.53) | PDE9AALDH1A1KDM4EHPGDMEN1 | |
| SCHEMBL18322246 | 0.83 | PDE9A (0.51) | PDE9AALDH1A1KDM4EHPGDMEN1 | |
| SCHEMBL5264870 | 0.82 | MAPT (0.57) | ALDH1A1KDM4EHPGDMEN1KMT2A | |
| SCHEMBL5264866 | 0.82 | MAPT (0.57) | ALDH1A1KDM4EHPGDMEN1KMT2A | |
| SCHEMBL27523327 | 0.80 | HPGD (0.50) | PDE9AALDH1A1KDM4EHPGDMEN1 | |
| SCHEMBL3883122 | 0.80 | HPSE (0.50) | PDE9AKDM4ETGFBR1SMN1; SMN2 | |
| SCHEMBL22907746 | 0.77 | MAP2 (0.53) | PDE9ATGFBR1MAPK14MAP2GAA | |
| SCHEMBL3877998 | 0.75 | PARP1 (0.48) | PDE9AMAPK14MAP2 | |
| SCHEMBL27791164 | 0.74 | DHODH (0.50) | ALDH1A1KDM4EHPGDMAPK14 | |
| SCHEMBL21292084 | 0.74 | TGFBR1 (0.44) | PDE9AALDH1A1KDM4EMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107787322-B | Tricyclic compounds and their use as phosphodiesterase inhibitors | 辉瑞大药厂 | 2023-07-07 | — | — | CN | disclosed |