Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 13/20 | 0.71 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | ACACB | O00763 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5261377 | 0.92 | GPR119 (0.73) | GPR119KMT2AMAPTCYP2C9CYP2C19 | |
| SCHEMBL5263947 | 0.91 | GPR119 (0.80) | GPR119KMT2AMAPTALDH1A1 | |
| SCHEMBL5265164 | 0.91 | GPR119 (0.72) | GPR119KMT2AMAPTCYP2C9CYP2C19 | |
| SCHEMBL5264597 | 0.89 | GPR119 (0.72) | GPR119KMT2ATRPV1ACACBALDH1A1 | |
| SCHEMBL1673689 | 0.88 | GPR119 (0.83) | GPR119KMT2AMAPTTDP1KDM4E | |
| SCHEMBL1673944 | 0.87 | GPR119 (0.76) | GPR119KMT2ATRPV1MAPTALDH1A1 | |
| SCHEMBL1673929 | 0.86 | GPR119 (0.80) | GPR119KMT2AMAPTTDP1CYP2C9 | |
| SCHEMBL1673748 | 0.86 | GPR119 (0.74) | GPR119KMT2ATRPV1MAPTALDH1A1 | |
| SCHEMBL1673922 | 0.86 | GPR119 (0.74) | GPR119KMT2AMAPT | |
| SCHEMBL1673657 | 0.86 | GPR119 (0.79) | GPR119KMT2AMAPTTDP1CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1599468-B1 | 1,2,3-TRISUBSTITUTED ARYL AND HETEROARYL DERIVATIVES AS MODULATORS OF METABOLISM AND THE PROPHYLAXIS AND TREATMENT OF DISORDERS RELATED THERETO SUCH AS DIABETES AND HYPERGLYCEMIA | ARENA PHARM INC (US) | 2007-10-03 | — | — | EP | claimed |