Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.36 |
| ▸ | HPGD | P15428 | 3/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.34 |
| ▸ | TSHR | P16473 | 3/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 2/20 | 0.34 |
| ▸ | ELANE | P08246 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4051768 | 0.99 | ADORA1 (0.36) | ALDH1A1HPGDNPSR1HIF1AADORA1 | |
| SCHEMBL4053868 | 0.94 | ALDH1A1 (0.40) | ALDH1A1HPGDNPSR1HIF1AADORA1 | |
| SCHEMBL5336492 | 0.93 | TP53 (0.36) | ALDH1A1HPGDNPSR1HIF1AADORA1 | |
| SCHEMBL4051583 | 0.93 | ADORA1 (0.39) | ALDH1A1HPGDNPSR1HIF1AADORA1 | |
| SCHEMBL5264015 | 0.89 | MEN1 (0.40) | ALDH1A1HPGDNPSR1HIF1AADORA1 | |
| SCHEMBL4053216 | 0.89 | NPSR1 (0.44) | ALDH1A1HPGDNPSR1HIF1AADORA1 | |
| SCHEMBL4056621 | 0.88 | PDE4B (0.44) | ALDH1A1HPGDNPSR1LMNASMN1; SMN2 | |
| SCHEMBL4055585 | 0.87 | KMT2A (0.41) | ALDH1A1HIF1AADORA1KDM4EHSD17B10 | |
| SCHEMBL4051471 | 0.87 | ADORA1 (0.37) | ALDH1A1HPGDNPSR1HIF1AADORA1 | |
| SCHEMBL4058334 | 0.86 | PDE4B (0.37) | ALDH1A1HPGDNPSR1ADORA1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1781621-A1 | PYRIDAZIN-3(2H)-ONE DERIVATIVES AND THEIR USE AS PDE4 INHIBITORS | Laboratorios Almirall, S.A. (ES) | 2007-05-09 | — | — | EP | disclosed |
| WO-2005123693-A1 | PYRIDAZIN-3(2H)-ONE DERIVATIVES AND THEIR USE AS PDE4 INHIBITORS | LABORATORIOS ALMIRALL, S.A. (ES) | 2005-12-29 | — | — | WO | disclosed |