Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | DAO | P14920 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5266608 | 0.80 | DAO (0.50) | MEN1CYP1A2KMT2ADAOPOLB | |
| SCHEMBL7584888 | 0.78 | MEN1 (0.47) | MEN1CYP1A2KMT2ADAOPOLB | |
| SCHEMBL6648995 | 0.78 | MEN1 (0.47) | MEN1CYP1A2KMT2ADAOPOLB | |
| SCHEMBL5265643 | 0.77 | DAO (0.50) | MEN1CYP1A2KMT2ADAOPOLB | |
| SCHEMBL14701887 | 0.76 | DAO (0.56) | MEN1CYP1A2KMT2ADAOPOLB | |
| SCHEMBL11431122 | 0.76 | DAO (0.60) | MEN1CYP1A2KMT2ADAOPOLB | |
| SCHEMBL7599845 | 0.75 | DAO (0.47) | MEN1CYP1A2KMT2ADAOPOLB | |
| SCHEMBL2256797 | 0.75 | DAO (0.47) | MEN1CYP1A2KMT2ADAOPOLB | |
| SCHEMBL444120 | 0.74 | DAO (0.58) | MEN1CYP1A2KMT2ADAOPOLB | |
| SCHEMBL739582 | 0.74 | CYP1A2 (0.63) | MEN1CYP1A2KMT2ADAOPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1753731-A2 | PYRIMIDIN-4-ONE DERIVATIVES AND THEIR USE AS P38 KINASE MODULATORS | Pharmacia Corporation (US) | 2007-02-21 | — | — | EP | disclosed |
| EP-1490064-A1 | SUBSTITUTED PYRIDINONES AS MODULATORS OF P38 MAP KINASE | Pharmacia Corporation (US) | 2004-12-29 | — | — | EP | disclosed |
| WO-2004087677-A2 | PYRIMIDIN-4-ONE DERIVATIVES AND THEIR USE AS P38 KINASE MODULATORS | PHARMACIA CORPORATION (US) | 2004-10-14 | — | — | WO | disclosed |
| WO-2003068230-A1 | SUBSTITUTED PYRIDINONES AS MODULATORS OF P38 MAP KINASE | PHARMACIA CORPORATION (US) | 2003-08-21 | — | — | WO | disclosed |