Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 5/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | MAPT | P10636 | 5/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | UBE2N | P61088 | 1/20 | 0.38 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | PDE4A | P27815 | 3/20 | 0.36 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4056170 | 0.95 | PDE4B (0.42) | PDE4BALDH1A1MAPTKDM4ENPSR1 | |
| SCHEMBL4052633 | 0.93 | PDE4B (0.43) | PDE4BALDH1A1MAPTKDM4ENPSR1 | |
| SCHEMBL4052874 | 0.91 | PDE4B (0.44) | PDE4BALDH1A1MAPTKDM4ENPSR1 | |
| SCHEMBL4054775 | 0.89 | PDE4B (0.46) | PDE4BALDH1A1MAPTKDM4ENPSR1 | |
| SCHEMBL4052248 | 0.87 | PDE4B (0.52) | PDE4BALDH1A1MAPTKDM4ENPSR1 | |
| SCHEMBL5262513 | 0.85 | PDE4B (0.39) | PDE4BALDH1A1MAPTKDM4ENPSR1 | |
| SCHEMBL4050541 | 0.83 | PDE4B (0.46) | PDE4BALDH1A1MAPTKDM4ENPSR1 | |
| SCHEMBL4053547 | 0.83 | PDE4B (0.56) | PDE4BALDH1A1MAPTKDM4ENPSR1 | |
| SCHEMBL4051493 | 0.82 | PDE4B (0.50) | PDE4BALDH1A1MAPTMEN1LMNA | |
| SCHEMBL4048548 | 0.82 | ALDH1A1 (0.50) | PDE4BALDH1A1MAPTKDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1781621-A1 | PYRIDAZIN-3(2H)-ONE DERIVATIVES AND THEIR USE AS PDE4 INHIBITORS | Laboratorios Almirall, S.A. (ES) | 2007-05-09 | — | — | EP | claimed |
| WO-2005123693-A1 | PYRIDAZIN-3(2H)-ONE DERIVATIVES AND THEIR USE AS PDE4 INHIBITORS | LABORATORIOS ALMIRALL, S.A. (ES) | 2005-12-29 | — | — | WO | claimed |