Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGMT | P16455 | 1/20 | 0.40 |
| ▸ | PNP | P00491 | 2/20 | 0.35 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.35 |
| ▸ | GDA | Q9Y2T3 | 1/20 | 0.35 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.34 |
| ▸ | MTOR | P42345 | 1/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.34 |
| ▸ | PDE4A | P27815 | 1/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.34 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.34 |
| ▸ | DPP4 | P27487 | 1/20 | 0.33 |
| ▸ | GBA1 | P04062 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17186408 | 0.86 | MGMT (0.40) | MGMTPNPPDPK1GDAPIK3CG | |
| Hydrochloric Acid SCHEMBL18605989 | 0.85 | MGMT (0.40) | MGMTPNPPDPK1GDAPIK3CG | |
| SCHEMBL22090217 | 0.74 | PNP (0.42) | MGMTPNPPDPK1GDASMN1; SMN2 | |
| SCHEMBL1533592 | 0.73 | SLC2A1 (0.41) | MGMTPNPPDPK1GDAPIK3CD | |
| SCHEMBL27310857 | 0.73 | MGMT (0.41) | MGMTPNPPIK3CGPIK3CAMTOR | |
| SCHEMBL2385930 | 0.73 | ADORA2B (0.50) | PNPPDPK1GDADPP4ALDH1A1 | |
| SCHEMBL29174358 | 0.73 | PNP (0.45) | PNPPDPK1GDAPDE4APDE4B | |
| SCHEMBL9806974 | 0.72 | PNP (0.44) | PNPPDPK1GDADPP4ALDH1A1 | |
| SCHEMBL4962859 | 0.71 | PDE4A (0.53) | MGMTPNPSMN1; SMN2PDE4APDE4B | |
| SCHEMBL6952184 | 0.71 | SLC2A1 (0.41) | PNPPDPK1GDAPIK3CGPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1838307-A1 | METHODS OF USING TEMOZOLOMIDE FORMULATION INTRATHECALLY IN THE TREATMENT OF CANCERS | SCHERING CORPORATION (US) | 2007-10-03 | — | — | EP | disclosed |
| WO-2006060464-A1 | METHODS OF USING TEMOZOLOMIDE FORMULATION INTRATHECALLY IN THE TREATMENT OF CANCERS | SCHERING CORPORATION (US) | 2006-06-08 | — | — | WO | disclosed |