Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.51 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | AKR1C3 | P42330 | 6/20 | 0.47 |
| ▸ | AKR1C2 | P52895 | 6/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5262043 | 0.88 | ALDH1A1 (0.45) | MKNK1MKNK2KDM4EMAPK10NPC1 | |
| SCHEMBL5379152 | 0.86 | AKR1C3 (0.63) | AKR1C3AKR1C2 | |
| SCHEMBL10487877 | 0.83 | SMN1; SMN2 (0.46) | KDM4EMAPK10NPC1RAB9ATP53 | |
| SCHEMBL27508231 | 0.81 | AKR1C3 (0.49) | KDM4EMAPK10NPC1RAB9ATP53 | |
| SCHEMBL22067718 | 0.79 | MKNK2 (0.55) | MKNK1MKNK2KDM4ENPC1RAB9A | |
| SCHEMBL28833380 | 0.78 | AKR1C3 (0.47) | KDM4EMAPK10NPC1RAB9ATP53 | |
| SCHEMBL28066427 | 0.78 | KMT2A (0.49) | KDM4EMAPK10NPC1RAB9ATP53 | |
| SCHEMBL165257 | 0.77 | KDM4E (0.55) | KDM4EMAPK10NPC1RAB9ATP53 | |
| SCHEMBL4934131 | 0.77 | PTPN1 (0.49) | KDM4EMAPK10NPC1RAB9ATP53 | |
| SCHEMBL10822663 | 0.77 | KDM4E (0.49) | KDM4ENPC1RAB9ASMN1; SMN2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1740551-A1 | HETEROCYCLIC AMIDE COMPOUND AND USE THEREOF AS AN MMP-13 INHIBITOR | Takeda Pharmaceutical Company Limited (JP) | 2007-01-10 | — | — | EP | disclosed |
| WO-2005105760-A1 | HETEROCYCLIC AMIDE COMPOUND AND USE THEREOF AS AN MMP-13 INHIBITOR | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2005-11-10 | — | — | WO | disclosed |