Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 16/20 | 0.60 |
| ▸ | JAK3 | P52333 | 16/20 | 0.60 |
| ▸ | SYK | P43405 | 4/20 | 0.59 |
| ▸ | JAK2 | O60674 | 7/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.51 |
| ▸ | TYK2 | P29597 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Formic Acid SCHEMBL524657 | 0.96 | SYK (0.57) | JAK1JAK3SYKJAK2CYP3A4 | |
| Formic Acid SCHEMBL29360088 | 0.96 | SYK (0.57) | JAK1JAK3SYKJAK2CYP3A4 | |
| SCHEMBL29609871 | 0.90 | JAK1 (0.64) | JAK1JAK3SYKJAK2CYP3A4 | |
| SCHEMBL341710 | 0.90 | JAK1 (0.64) | JAK1JAK3SYKJAK2CYP3A4 | |
| SCHEMBL15389271 | 0.85 | JAK1 (0.61) | JAK1JAK3JAK2CYP3A4CYP1A2 | |
| SCHEMBL15389476 | 0.83 | JAK1 (0.59) | JAK1JAK3JAK2CYP3A4CYP1A2 | |
| SCHEMBL29610246 | 0.82 | JAK1 (0.64) | JAK1JAK3SYKJAK2CYP3A4 | |
| SCHEMBL340841 | 0.82 | JAK1 (0.64) | JAK1JAK3SYKJAK2CYP3A4 | |
| SCHEMBL656397 | 0.81 | SYK (0.86) | JAK1JAK3SYK | |
| SCHEMBL657850 | 0.81 | SYK (0.86) | JAK1JAK3SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2598500-B1 | COMPOSITIONS AND METHODS FOR INHIBITION OF THE JAK PATHWAY | RIGEL PHARMACEUTICALS INC (US) | 2021-05-19 | — | — | EP | claimed |
| EP-2598500-A1 | COMPOSITIONS AND METHODS FOR INHIBITION OF THE JAK PATHWAY | Rigel Pharmaceuticals, Inc. (US) | 2013-06-05 | — | — | EP | claimed |
| WO-2012015972-A1 | COMPOSITIONS AND METHODS FOR INHIBITION OF THE JAK PATHWAY | RIGEL PHARMACEUTICALS, INC. (US) | 2012-02-02 | — | — | WO | claimed |
| US-20130310340-A1 | METHOD OF TREATING MUSCULAR DEGRADATION | RIGEL PHARMACEUTICALS, INC. (US) | 2013-11-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130310340-A1 | METHOD OF TREATING MUSCULAR DEGRADATION | PYGM, CKMT1A; CKMT1B, SMN1; SMN2 | JAK1 4796/4885JAK3 4792/4885SYK 4857/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.