Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | PLA2G7 | Q13093 | 6/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.40 |
| ▸ | ATR | Q13535 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5265886 | 0.87 | LMNA (0.45) | LMNANPC1RAB9AKMT2ATSHR | |
| SCHEMBL13816898 | 0.85 | NPC1 (0.47) | LMNANPC1RAB9AKMT2ATSHR | |
| SCHEMBL5268756 | 0.83 | LMNA (0.42) | LMNANPC1RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL5266716 | 0.83 | LMNA (0.69) | LMNANPC1RAB9AKMT2ATSHR | |
| SCHEMBL5270560 | 0.83 | LMNA (0.54) | LMNANPC1RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL5270600 | 0.82 | LMNA (0.48) | LMNAKMT2ATSHRALDH1A1SMN1; SMN2 | |
| SCHEMBL5268963 | 0.82 | LMNA (0.46) | LMNANPC1RAB9AKMT2ATSHR | |
| SCHEMBL5269706 | 0.81 | LMNA (0.55) | LMNANPC1RAB9AKMT2ATSHR | |
| SCHEMBL5272339 | 0.81 | LMNA (0.54) | LMNANPC1RAB9AKMT2AALDH1A1 | |
| SCHEMBL5271687 | 0.81 | KCNA5 (0.56) | LMNANPC1RAB9AKMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1847531-A1 | PYRAZOLE COMPOUND | Takeda Pharmaceutical Company Limited (JP) | 2007-10-24 | — | — | EP | disclosed |