SCHEMBL5267380

SCHEMBL5267380

O=C(O)Oc1ccc2ncccc2c1

nearest known ligand 0.68

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.68
HTT P42858 2/20 0.53
ALOX15 P16050 1/20 0.53
NPC1 O15118 3/20 0.51
POLB P06746 2/20 0.51
MAPT P10636 2/20 0.51
MEN1 O00255 1/20 0.51
KMT2A Q03164 1/20 0.51
CYP3A4 P08684 2/20 0.50
RAB9A P51151 2/20 0.50
MCL1 Q07820 2/20 0.49
PABPC1 P11940 1/20 0.49
PLK1 P53350 1/20 0.49
SMN1; SMN2 Q16637 2/20 0.47
KDM4E B2RXH2 1/20 0.47
TP53 P04637 1/20 0.47
HSP90AA1 P07900 1/20 0.47
HSP90AB1 P08238 1/20 0.47
TSHR P16473 1/20 0.47
CASP1 P29466 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3161907 0.89 ALDH1A1 (0.71) ALDH1A1HTTALOX15NPC1POLB
Hydrochloric Acid SCHEMBL27728003 0.87 ALDH1A1 (0.69) ALDH1A1HTTALOX15NPC1POLB
SCHEMBL933273 0.87 CYP3A4 (0.56) ALDH1A1HTTALOX15NPC1POLB
SCHEMBL3171559 0.85 ALDH1A1 (0.67) ALDH1A1HTTALOX15NPC1POLB
SCHEMBL6985088 0.85 ALDH1A1 (0.67) ALDH1A1HTTALOX15NPC1POLB
SCHEMBL2468542 0.84 KMT2A (0.67) ALDH1A1HTTALOX15NPC1POLB
SCHEMBL19924516 0.84 ALDH1A1 (0.69) ALDH1A1HTTALOX15NPC1POLB
SCHEMBL19924517 0.83 ALDH1A1 (0.64) ALDH1A1HTTALOX15NPC1POLB
SCHEMBL2494747 0.83 ALDH1A1 (0.72) ALDH1A1HTTALOX15NPC1POLB
SCHEMBL29541514 0.83 ALDH1A1 (0.63) ALDH1A1HTTALOX15NPC1POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-108697709-A Methods for treating huntington's disease PTC医疗公司 2018-10-23 CN claimed
EP-1320523-B1 BRANCHED CHAIN AMINO ACID-DEPENDENT AMINOTRANSFERASE INHIBITORS AND THEIR USE IN THE TREATMENT OF NEURODEGENERATIVE DISEASES WARNER LAMBERT CO (US) 2005-06-22 EP claimed
EP-0730597-B1 HETEROCYCLIC ESTERS OF RAPAMYCIN AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AMERICAN HOME PROD (US) 2001-03-07 EP claimed
EP-0639570-A1 Process for the preparation of aromatic carboxylic acids BASF Aktiengesellschaft (DE) 1995-02-22 EP claimed
EP-1448530-B1 HETEROARYL CARBOXYLIC ACID AMIDES BAYER HEALTHCARE AG (DE) 2007-10-03 EP disclosed
EP-1448530-A1 HETEROARYL CARBOXYLIC ACID AMIDES Bayer HealthCare AG (DE) 2004-08-25 EP disclosed
EP-0944582-B1 KETOBENZAMIDES AS CALPAIN INHIBITORS ABBOTT GMBH & CO KG (DE) 2003-07-02 EP disclosed
WO-2003043991-A1 HETEROARYL CARBOXYLIC ACID AMIDES BAYER HEALTHCARE AG (DE) 2003-05-30 WO disclosed
EP-0944582-A1 KETOBENZAMIDES AS CALPAIN INHIBITORS BASF AKTIENGESELLSCHAFT (DE) 1999-09-29 EP disclosed
EP-0707656-B1 BIOTECHNOLOGICAL PROCESS FOR PRODUCING ALCOHOLS, ALDEHYDES AND CARBOXYLIC ACIDS BASF AG (DE) 1998-09-02 EP disclosed
WO-1998025883-A1 KETOBENZAMIDES AS CALPAIN INHIBITORS BASF AKTIENGESELLSCHAFT (DE) 1998-06-18 WO disclosed
EP-0675111-A2 Process for the preparation of 6-hydroxymethyl-quinolines BASF AKTIENGESELLSCHAFT (DE) 1995-10-04 EP disclosed
EP-0639570-A1 Process for the preparation of aromatic carboxylic acids BASF Aktiengesellschaft (DE) 1995-02-22 EP disclosed