Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.63 |
| ▸ | TP53 | P04637 | 2/20 | 0.63 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.59 |
| ▸ | TSHR | P16473 | 2/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.52 |
| ▸ | HPGD | P15428 | 6/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | POLB | P06746 | 5/20 | 0.52 |
| ▸ | MAPT | P10636 | 5/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.50 |
| ▸ | ESR1 | P03372 | 1/20 | 0.50 |
| ▸ | APEX1 | P27695 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5269122 | 0.85 | ALDH1A1 (0.54) | SMN1; SMN2TP53HSD17B10TSHRALDH1A1 | |
| SCHEMBL5270571 | 0.85 | KMT2A (0.59) | SMN1; SMN2HSD17B10TSHRALDH1A1HPGD | |
| SCHEMBL5265275 | 0.84 | ALDH1A1 (0.54) | SMN1; SMN2TP53HSD17B10TSHRKDM4E | |
| SCHEMBL5270376 | 0.84 | TSHR (0.50) | SMN1; SMN2TP53HSD17B10TSHRKDM4E | |
| SCHEMBL5270730 | 0.84 | HPGD (0.69) | SMN1; SMN2TP53HSD17B10TSHRKDM4E | |
| SCHEMBL5266740 | 0.82 | TDP1 (0.49) | SMN1; SMN2TP53HSD17B10TSHRKDM4E | |
| SCHEMBL4284612 | 0.82 | ALDH1A1 (0.51) | SMN1; SMN2TP53HSD17B10TSHRKDM4E | |
| SCHEMBL5267614 | 0.81 | ALDH1A1 (0.53) | SMN1; SMN2TP53HSD17B10TSHRALDH1A1 | |
| SCHEMBL5269978 | 0.81 | ALDH1A1 (0.54) | SMN1; SMN2TP53TSHRKDM4EALDH1A1 | |
| SCHEMBL5268206 | 0.80 | HPGD (0.53) | TP53HSD17B10TSHRKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1847531-A1 | PYRAZOLE COMPOUND | Takeda Pharmaceutical Company Limited (JP) | 2007-10-24 | — | — | EP | disclosed |