Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 9/20 | 0.59 |
| ▸ | DRD3 | P35462 | 9/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | HTR2A | P28223 | 2/20 | 0.51 |
| ▸ | HTR1A | P08908 | 1/20 | 0.51 |
| ▸ | DRD4 | P21917 | 1/20 | 0.51 |
| ▸ | HTR2C | P28335 | 1/20 | 0.51 |
| ▸ | HTR2B | P41595 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5272696 | 0.92 | DRD2 (0.62) | DRD2DRD3HTR2AHTR1ADRD4 | |
| SCHEMBL5273735 | 0.91 | DRD2 (0.61) | DRD2DRD3HTR2AHTR1ADRD4 | |
| SCHEMBL13630125 | 0.89 | DRD2 (0.66) | DRD2DRD3HTR2AHTR1ADRD4 | |
| SCHEMBL4483665 | 0.89 | DRD2 (0.66) | DRD2DRD3HTR2AHTR1ADRD4 | |
| SCHEMBL13630038 | 0.87 | DRD2 (0.61) | DRD2DRD3HTR2AHTR1ADRD4 | |
| SCHEMBL3869397 | 0.87 | DRD2 (0.61) | DRD2DRD3HTR2AHTR1ADRD4 | |
| SCHEMBL4496109 | 0.87 | DRD2 (0.65) | DRD2DRD3HTR2AKDM4EALDH1A1 | |
| SCHEMBL13629882 | 0.87 | DRD2 (0.65) | DRD2DRD3HTR2AKDM4EALDH1A1 | |
| SCHEMBL13629900 | 0.86 | DRD2 (0.67) | DRD2DRD3HTR2AKDM4EALDH1A1 | |
| SCHEMBL4486488 | 0.86 | DRD2 (0.67) | DRD2DRD3HTR2AKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1870405-A1 | Carbonylated (Aza)cyclohexanes as dopamine D3 receptor ligands | BIOPROJET (FR) | 2007-12-26 | — | — | EP | claimed |
| EP-1870405-A1 | Carbonylated (Aza)cyclohexanes as dopamine D3 receptor ligands | BIOPROJET (FR) | 2007-12-26 | — | — | EP | disclosed |