Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | AR | P10275 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 6/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.43 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | MC4R | P32245 | 2/20 | 0.42 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9926081 | 1.00 | SMN1; SMN2 (0.48) | SMN1; SMN2ARMAPTALDH1A1NR4A1 | |
| SCHEMBL9925998 | 0.89 | AR (0.46) | SMN1; SMN2ARMAPTKMT2AMC4R | |
| SCHEMBL5270813 | 0.89 | AR (0.46) | SMN1; SMN2ARMAPTKMT2AMC4R | |
| SCHEMBL9926090 | 0.89 | AR (0.46) | ARMC4R | |
| SCHEMBL9926064 | 0.88 | SMN1; SMN2 (0.53) | SMN1; SMN2ARMAPTALDH1A1NR4A1 | |
| SCHEMBL9926111 | 0.87 | MC4R (0.56) | SMN1; SMN2ALDH1A1MEN1KMT2ATSHR | |
| SCHEMBL5265693 | 0.87 | SMN1; SMN2 (0.52) | SMN1; SMN2ARMAPTALDH1A1NR4A1 | |
| SCHEMBL13987559 | 0.87 | SMN1; SMN2 (0.52) | SMN1; SMN2ARMAPTALDH1A1NR4A1 | |
| SCHEMBL9926099 | 0.86 | SIGMAR1 (0.51) | SMN1; SMN2MAPTALDH1A1MEN1KMT2A | |
| SCHEMBL9926068 | 0.86 | MAPT (0.45) | SMN1; SMN2ARMAPTALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1836180-A2 | SULFONYL PYRROLIDINES, METHOD FOR PRODUCING THE SAME AND THEIR USE AS DRUGS | sanofi-aventis (FR) | 2007-09-26 | — | — | EP | disclosed |
| WO-2006072393-A2 | SULFONYL PYRROLIDINES, METHOD FOR PRODUCING THE SAME AND THEIR USE AS DRUGS | SANOFI-AVENTIS (DE) | 2006-07-13 | — | — | WO | disclosed |