Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.48 |
| ▸ | HTR2C | P28335 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | PIM1 | P11309 | 1/20 | 0.41 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | KHK | P50053 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2246683 | 1.00 | NOTUM (0.48) | NOTUMHTR2CALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL2249111 | 1.00 | NOTUM (0.48) | NOTUMHTR2CALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL21281577 | 0.81 | ADRB1 (0.61) | HTR2CALDH1A1SMN1; SMN2LMNATSHR | |
| SCHEMBL21268746 | 0.81 | ADRB1 (0.61) | HTR2CALDH1A1SMN1; SMN2LMNATSHR | |
| SCHEMBL21268764 | 0.81 | ADRB1 (0.61) | HTR2CALDH1A1SMN1; SMN2LMNATSHR | |
| SCHEMBL23744700 | 0.81 | HTR2C (0.59) | NOTUMHTR2CALDH1A1LMNAKHK | |
| SCHEMBL5631643 | 0.81 | XIAP (0.45) | HTR2CALDH1A1LMNAKDM4EKHK | |
| SCHEMBL5631645 | 0.81 | XIAP (0.45) | HTR2CALDH1A1LMNAKDM4EKHK | |
| SCHEMBL3219365 | 0.81 | HTR2C (0.59) | NOTUMHTR2CALDH1A1LMNAKHK | |
| SCHEMBL3219375 | 0.81 | HTR2C (0.59) | NOTUMHTR2CALDH1A1LMNAKHK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1771421-A1 | N-HYDROXYAMIDE DERIVATIVES AND USE THEREOF | Applied Research Systems ARS Holding N.V. (AN) | 2007-04-11 | — | — | EP | claimed |
| WO-2006010751-A1 | N-HYDROXYAMIDE DERIVATIVES AND USE THEREOF | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (AN) | 2006-02-02 | — | — | WO | claimed |
| CN-102869660-A | Aminothiazolones as estrogen related receptor-alpha modulators | JANSSEN PHARMACEUTICA NV | 2013-01-09 | — | — | CN | disclosed |
| CN-102834392-A | Aminothiazolones as estrogen related receptor-alpha modulators | JANSSEN PHARMACEUTICA NV | 2012-12-19 | — | — | CN | disclosed |
| CN-102770429-A | Substituted aminothiazolone indazoles as estrogen related receptor-alpha modulators | JANSSEN PHARMACEUTICA NV | 2012-11-07 | — | — | CN | disclosed |
| CN-101102760-A | Methods and agents for treating immunoinflammatory disorders | COMBINATORX (US) | 2008-01-09 | — | — | CN | disclosed |
| EP-1771421-A1 | N-HYDROXYAMIDE DERIVATIVES AND USE THEREOF | Applied Research Systems ARS Holding N.V. (AN) | 2007-04-11 | — | — | EP | disclosed |
| WO-2006010751-A1 | N-HYDROXYAMIDE DERIVATIVES AND USE THEREOF | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (AN) | 2006-02-02 | — | — | WO | disclosed |