Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AVPR2 | P30518 | 5/20 | 0.61 |
| ▸ | AVPR1A | P37288 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | DRD4 | P21917 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5236886 | 0.86 | AVPR2 (0.64) | AVPR2AVPR1ALMNA | |
| SCHEMBL9059366 | 0.85 | AVPR2 (0.61) | AVPR2AVPR1AMAPTHPGDALDH1A1 | |
| SCHEMBL8818791 | 0.83 | AVPR2 (0.51) | AVPR2MAPTNPC1LMNAHTT | |
| SCHEMBL5232606 | 0.80 | KMT2A (0.43) | AVPR2AVPR1AMAPTNPC1LMNA | |
| SCHEMBL5233202 | 0.76 | AVPR2 (0.81) | AVPR2AVPR1A | |
| SCHEMBL5236617 | 0.76 | AVPR1A (0.55) | AVPR2AVPR1AMAPTNPC1LMNA | |
| SCHEMBL5233480 | 0.75 | KMT2A (0.39) | AVPR2AVPR1AMAPTNPC1LMNA | |
| SCHEMBL5233477 | 0.75 | KMT2A (0.39) | AVPR2AVPR1AMAPTNPC1LMNA | |
| SCHEMBL5235169 | 0.75 | AVPR2 (1.00) | AVPR2AVPR1A | |
| SCHEMBL5233013 | 0.74 | AVPR2 (0.64) | AVPR2AVPR1AMAPTNPC1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0804440-B1 | TRICYCLIC BENZAZEPINE VASOPRESSIN ANTAGONISTS | WYETH CORP (US) | 2007-12-19 | — | — | EP | disclosed |
| WO-1996022295-A1 | TRICYCLIC BENZAZEPINE VASOPRESSIN ANTAGONISTS | AMERICAN CYANAMID COMPANY (US) | 1996-07-25 | — | — | WO | disclosed |
| US-5532235-A | TO TREAT EXCESS RENAL REABSORPTION | AMERICAN CYANAMID COMPANY (US) | 1996-07-02 | — | — | US | disclosed |