SCHEMBL5272001

SCHEMBL5272001

CNCC(CC1CC1)c1cccc(C#N)c1

nearest known ligand 0.38

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
TACR1 P25103 1/20 0.38
MRGPRX1 Q96LB2 1/20 0.38
KMT2A Q03164 2/20 0.37
DRD2 P14416 4/20 0.36
DRD3 P35462 4/20 0.36
TSHR P16473 2/20 0.36
SLC6A4 P31645 3/20 0.36
MEN1 O00255 1/20 0.35
GLA P06280 1/20 0.35
NPSR1 Q6W5P4 1/20 0.35
REN P00797 1/20 0.35
SLC6A2 P23975 2/20 0.34
SLC6A3 Q01959 1/20 0.34
P2RX7 Q99572 1/20 0.34
CNR1 P21554 1/20 0.34
BCDIN3D Q7Z5W3 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5146737 0.95 KMT2A (0.43) TACR1MRGPRX1KMT2ADRD2DRD3
SCHEMBL4562477 0.95 KMT2A (0.41) TACR1MRGPRX1KMT2ADRD2DRD3
SCHEMBL4691467 0.94 TSHR (0.44) TACR1MRGPRX1KMT2ADRD2DRD3
SCHEMBL4689407 0.81 NOTCH1 (0.45)
SCHEMBL3374707 0.74 CNR1 (0.40) TACR1MRGPRX1DRD2DRD3SLC6A4
SCHEMBL6666064 0.74 HIF1A (0.61) KMT2ADRD2DRD3TSHRMEN1
SCHEMBL5721057 0.74 CNR1 (0.56) CNR1
Hydrochloric Acid SCHEMBL5721052 0.73 CNR1 (0.55) CNR1
SCHEMBL21226969 0.72 TSHR (0.46) TACR1MRGPRX1KMT2ADRD2DRD3
SCHEMBL12488294 0.71 S1PR1 (0.45) DRD2DRD3TSHRSLC6A4GLA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1490043-A4 SPIROCYCLIC AMIDES AS CANNABINOID RECEPTOR MODULATORS MERCK & CO INC (US) 2007-05-30 EP disclosed
EP-1499306-A4 BICYCLIC AMIDES MERCK & CO INC (US) 2007-03-28 EP disclosed
EP-1499306-A2 BICYCLIC AMIDES Merck & Co., Inc. (US) 2005-01-26 EP disclosed
EP-1490043-A2 SPIROCYCLIC AMIDES AS CANNABINOID RECEPTOR MODULATORS Merck & Co., Inc. (US) 2004-12-29 EP disclosed
WO-2003086288-A2 BICYCLIC AMIDES MERCK & CO., INC. (US) 2003-10-23 WO disclosed
WO-2003082190-A2 SPIROCYCLIC AMIDES AS CANNABINOID RECEPTOR MODULATORS MERCK & CO., INC. (US) 2003-10-09 WO disclosed