Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 | P30542 | 5/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.67 |
| ▸ | DOT1L | Q8TEK3 | 2/20 | 0.67 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.67 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.67 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.67 |
| ▸ | DPP4 | P27487 | 1/20 | 0.67 |
| ▸ | MEN1 | O00255 | 1/20 | 0.67 |
| ▸ | SLC28A1 | O00337 | 1/20 | 0.67 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.67 |
| ▸ | SLC28A2 | O43868 | 1/20 | 0.67 |
| ▸ | GAPDH | P04406 | 1/20 | 0.67 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.67 |
| ▸ | STAT6 | P42226 | 1/20 | 0.67 |
| ▸ | PI4KA | P42356 | 1/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.67 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.67 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.67 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.67 |
| ▸ | SLC28A3 | Q9HAS3 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1800135 | 1.00 | ADORA1 (0.67) | ADORA1SMN1; SMN2DOT1LADORA3ADORA2A | |
| SCHEMBL11889844 | 1.00 | ADORA1 (0.67) | ADORA1SMN1; SMN2DOT1LADORA3ADORA2A | |
| SCHEMBL11760829 | 1.00 | ADORA1 (0.67) | ADORA1SMN1; SMN2DOT1LADORA3ADORA2A | |
| SCHEMBL11680804 | 0.92 | ADORA1 (0.67) | ADORA1SMN1; SMN2DOT1LADORA3ADORA2A | |
| SCHEMBL11680796 | 0.92 | ADORA1 (0.67) | ADORA1SMN1; SMN2DOT1LADORA3ADORA2A | |
| SCHEMBL11679876 | 0.89 | ADORA1 (0.73) | ADORA1SMN1; SMN2DOT1LADORA3ADORA2A | |
| SCHEMBL7435435 | 0.87 | AHCY (0.71) | ADORA1SMN1; SMN2DOT1LADORA3ADORA2A | |
| SCHEMBL5581331 | 0.86 | ADORA1 (0.69) | ADORA1SMN1; SMN2DOT1LADORA3ADORA2A | |
| SCHEMBL41361 | 0.86 | ADORA1 (0.74) | ADORA1SMN1; SMN2DOT1LADORA3ADORA2A | |
| SCHEMBL15788449 | 0.86 | ADORA1 (0.74) | ADORA1SMN1; SMN2DOT1LADORA3ADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1848718-A1 | INHIBITORS OF E1 ACTIVATING ENZYMES | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2007-10-31 | — | — | EP | disclosed |
| WO-2006084281-A1 | INHIBITORS OF E1 ACTIVATING ENZYMES | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2006-08-10 | — | — | WO | disclosed |