Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 2/20 | 0.44 |
| ▸ | CASP3 | P42574 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.39 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.39 |
| ▸ | IP6K3 | Q96PC2 | 1/20 | 0.39 |
| ▸ | IP6K2 | Q9UHH9 | 1/20 | 0.39 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | HPSE | Q9Y251 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | NAMPT | P43490 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3845554 | 0.92 | KMT2A (0.46) | BACE1CASP3SMN1; SMN2ALDH1A1NPC1 | |
| SCHEMBL20710161 | 0.88 | BACE1 (0.46) | BACE1CASP3ALDH1A1KMT2AMEN1 | |
| SCHEMBL6655582 | 0.87 | KMT2A (0.41) | BACE1CASP3SMN1; SMN2ALDH1A1NPC1 | |
| SCHEMBL3143475 | 0.86 | BACE1 (0.46) | BACE1CASP3SMN1; SMN2RAB9AKMT2A | |
| SCHEMBL6770244 | 0.86 | BACE1 (0.46) | BACE1CASP3SMN1; SMN2RAB9AKMT2A | |
| SCHEMBL5270139 | 0.86 | BACE1 (0.46) | BACE1CASP3SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL14477231 | 0.86 | ROCK2 (0.44) | BACE1SMN1; SMN2KMT2AMEN1MAPT | |
| SCHEMBL3157920 | 0.85 | BACE1 (0.42) | BACE1CASP3SMN1; SMN2NPC1LMNA | |
| SCHEMBL480667 | 0.85 | KMT2A (0.44) | BACE1SMN1; SMN2ALDH1A1NPC1LMNA | |
| SCHEMBL480665 | 0.85 | KMT2A (0.44) | BACE1SMN1; SMN2ALDH1A1NPC1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1830842-A1 | MEDICAMENTS FOR THE TREATMENT OR PREVENTION OF FIBROTIC DISEASES | Boehringer Ingelheim International GmbH (DE) | 2007-09-12 | — | — | EP | disclosed |
| WO-2006067168-A1 | MEDICAMENTS FOR THE TREATMENT OR PREVENTION OF FIBROTIC DISEASES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2006-06-29 | — | — | WO | disclosed |