Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | PKM | P14618 | 2/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | ALPG | P10696 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | HTR6 | P50406 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.43 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.43 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18547216 | 0.90 | MAPT (0.58) | MAPTKMT2AMEN1MAPK1LMNA | |
| SCHEMBL1748266 | 0.88 | MAPT (0.51) | MAPTKMT2AMEN1MAPK1LMNA | |
| SCHEMBL5279041 | 0.85 | MAPT (0.51) | MAPTKMT2AMEN1PKMTDP1 | |
| SCHEMBL14993374 | 0.81 | MAPT (0.50) | MAPTKMT2AMEN1MAPK1LMNA | |
| SCHEMBL16036332 | 0.81 | MAPT (0.56) | MAPTKMT2APKMTDP1HTR6 | |
| SCHEMBL5271583 | 0.79 | KAT2B (0.49) | MAPTKMT2AMEN1MAPK1LMNA | |
| SCHEMBL5021178 | 0.78 | MAPT (0.51) | MAPTKMT2AMEN1MAPK1LMNA | |
| SCHEMBL5273517 | 0.77 | HTR6 (0.79) | MAPTSMN1; SMN2HTR6CYP1A2CYP3A4 | |
| SCHEMBL18547062 | 0.77 | MAPT (0.44) | MAPTKMT2AMEN1MAPK1LMNA | |
| SCHEMBL6432531 | 0.76 | MAPT (0.50) | MAPTKMT2AMEN1MAPK1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1856075-A1 | SUBSTITUTED ARYLAMINE COMPOUNDS AND THEIR USE AS 5-HT6 MODULATORS | Epix Delaware, Inc. (US) | 2007-11-21 | — | — | EP | disclosed |
| WO-2006081332-A1 | SUBSTITUTED ARYLAMINE COMPOUNDS AND THEIR USE AS 5-HT6 MODULATORS | EPIX DELAWARE, INC. (US) | 2006-08-03 | — | — | WO | disclosed |