Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IL2 | P60568 | 4/20 | 1.00 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | MAPK11 | Q15759 | 11/20 | 0.47 |
| ▸ | MAPK14 | Q16539 | 11/20 | 0.47 |
| ▸ | MAPK13 | O15264 | 6/20 | 0.47 |
| ▸ | MAPK12 | P53778 | 6/20 | 0.47 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.46 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.46 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.42 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5274000 | 0.91 | IL2 (0.83) | IL2TP53SMN1; SMN2MAPK11MAPK14 | |
| SCHEMBL5268528 | 0.91 | IL2 (0.83) | IL2TP53SMN1; SMN2MAPK11MAPK14 | |
| SCHEMBL5270337 | 0.90 | IL2 (0.82) | IL2TP53SMN1; SMN2MAPK11MAPK14 | |
| SCHEMBL8261510 | 0.88 | IL2 (0.79) | IL2MAPK11MAPK14MAPK13MAPK12 | |
| SCHEMBL5272414 | 0.88 | IL2 (0.79) | IL2MAPK11MAPK14MAPK13MAPK12 | |
| SCHEMBL8261507 | 0.83 | IL2 (0.71) | IL2MAPK11MAPK14MAPK13MAPK12 | |
| SCHEMBL5268719 | 0.82 | IL2 (0.70) | IL2TP53SMN1; SMN2MAPK11MAPK14 | |
| SCHEMBL5274940 | 0.82 | IL2 (0.69) | IL2TP53SMN1; SMN2MAPK11MAPK14 | |
| SCHEMBL8262611 | 0.82 | IL2 (0.69) | IL2MAPK11MAPK14MAPK13MAPK12 | |
| SCHEMBL5268631 | 0.81 | IL2 (0.81) | IL2TP53SMN1; SMN2MAPK11MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8802721-B2 | Thiophene compounds for inflammation and immune-related uses | SYNTA PHARMACEUTICALS CORP. (US) | 2014-08-12 | — | — | US | claimed |
| EP-1846388-A1 | THIOPHENE COMPOUNDS FOR INFLAMMATION AND IMMUNE-RELATED USES | Synta Pharmaceuticals Corporation (US) | 2007-10-24 | — | — | EP | claimed |
| US-20060199845-A1 | Thiophene compounds for inflammation and immune-related uses | SYNTA PHARMACEUTICALS CORP. (US) | 2006-09-07 | — | — | US | claimed |
| WO-2006081389-A1 | THIOPHENE COMPOUNDS FOR INFLAMMATION AND IMMUNE-RELATED USES | SYNTA PHARMACEUTICALS CORP. (US) | 2006-08-03 | — | — | WO | claimed |
| US-8802721-B2 | Thiophene compounds for inflammation and immune-related uses | SYNTA PHARMACEUTICALS CORP. (US) | 2014-08-12 | — | — | US | disclosed |
| US-8802721-B2 | Thiophene compounds for inflammation and immune-related uses | SYNTA PHARMACEUTICALS CORP. (US) | 2014-08-12 | — | — | US | disclosed |
| US-8802721-B2 | Thiophene compounds for inflammation and immune-related uses | SYNTA PHARMACEUTICALS CORP. (US) | 2014-08-12 | — | — | US | disclosed |
| EP-1846388-A1 | THIOPHENE COMPOUNDS FOR INFLAMMATION AND IMMUNE-RELATED USES | Synta Pharmaceuticals Corporation (US) | 2007-10-24 | — | — | EP | disclosed |
| US-20060199845-A1 | Thiophene compounds for inflammation and immune-related uses | SYNTA PHARMACEUTICALS CORP. (US) | 2006-09-07 | — | — | US | disclosed |
| WO-2006081389-A1 | THIOPHENE COMPOUNDS FOR INFLAMMATION AND IMMUNE-RELATED USES | SYNTA PHARMACEUTICALS CORP. (US) | 2006-08-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060199845-A1 | Thiophene compounds for inflammation and immune-related uses | CXCR2, TPMT, CXCR1 | IL2 40/4885TP53 486/4885SMN1; SMN2 4837/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.