Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IL2 | P60568 | 3/20 | 0.69 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.43 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.43 |
| ▸ | MAPK11 | Q15759 | 11/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 11/20 | 0.41 |
| ▸ | MAPK13 | O15264 | 6/20 | 0.41 |
| ▸ | MAPK12 | P53778 | 6/20 | 0.41 |
| ▸ | STIM1 | Q13586 | 2/20 | 0.41 |
| ▸ | ORAI1 | Q96D31 | 2/20 | 0.41 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.38 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8263025 | 0.92 | IL2 (0.66) | IL2MAPK11MAPK14MAPK13MAPK12 | |
| SCHEMBL8263035 | 0.91 | IL2 (0.66) | IL2S1PR2S1PR4MAPK11MAPK14 | |
| SCHEMBL8263026 | 0.83 | IL2 (0.65) | IL2MAPK11MAPK14MAPK13MAPK12 | |
| SCHEMBL8262108 | 0.83 | IL2 (0.56) | IL2S1PR2S1PR4MAPK11MAPK14 | |
| SCHEMBL5273629 | 0.82 | IL2 (1.00) | IL2S1PR2S1PR4MAPK11MAPK14 | |
| SCHEMBL5274000 | 0.80 | IL2 (0.83) | IL2S1PR2S1PR4MAPK11MAPK14 | |
| SCHEMBL5270337 | 0.79 | IL2 (0.82) | IL2S1PR2S1PR4MAPK11MAPK14 | |
| SCHEMBL8261510 | 0.79 | IL2 (0.79) | IL2S1PR2S1PR4MAPK11MAPK14 | |
| SCHEMBL8263089 | 0.78 | IL2 (0.68) | IL2S1PR2S1PR4STIM1ORAI1 | |
| SCHEMBL8261504 | 0.78 | IL2 (0.68) | IL2S1PR2S1PR4MAPK11MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006081389-A1 | THIOPHENE COMPOUNDS FOR INFLAMMATION AND IMMUNE-RELATED USES | SYNTA PHARMACEUTICALS CORP. (US) | 2006-08-03 | — | — | WO | disclosed |