Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC29A1 | Q99808 | 14/20 | 0.77 |
| ▸ | STAT6 | P42226 | 1/20 | 0.59 |
| ▸ | TP53 | P04637 | 1/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.58 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.58 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.58 |
| ▸ | SLC28A3 | Q9HAS3 | 1/20 | 0.58 |
| ▸ | BLM | P54132 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1795761 | 0.93 | SLC29A1 (0.76) | SLC29A1STAT6TP53CYP3A4HIF1A | |
| SCHEMBL24505818 | 0.83 | SLC29A1 (0.76) | SLC29A1STAT6TP53CYP3A4HIF1A | |
| SCHEMBL20435031 | 0.83 | SLC29A1 (0.72) | SLC29A1STAT6TP53CYP3A4HIF1A | |
| SCHEMBL20434985 | 0.81 | SLC29A1 (0.70) | SLC29A1STAT6TP53CYP3A4HIF1A | |
| SCHEMBL24505763 | 0.81 | SLC29A1 (0.70) | SLC29A1STAT6TP53CYP3A4HIF1A | |
| SCHEMBL1798057 | 0.77 | ADORA3 (0.64) | SLC29A1TP53 | |
| SCHEMBL18631605 | 0.77 | SLC29A1 (0.59) | SLC29A1STAT6TP53CYP3A4HIF1A | |
| SCHEMBL20097181 | 0.76 | — | — | |
| SCHEMBL27424276 | 0.76 | SLC29A1 (0.79) | SLC29A1STAT6TP53CYP3A4HIF1A | |
| SCHEMBL23323472 | 0.76 | SLC29A1 (0.79) | SLC29A1STAT6TP53CYP3A4HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1848718-A1 | INHIBITORS OF E1 ACTIVATING ENZYMES | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2007-10-31 | — | — | EP | disclosed |
| WO-2006084281-A1 | INHIBITORS OF E1 ACTIVATING ENZYMES | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2006-08-10 | — | — | WO | disclosed |