Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 19/20 | 0.44 |
| ▸ | CTSD | P07339 | 1/20 | 0.44 |
| ▸ | CTSE | P14091 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5272452 | 0.90 | REN (0.54) | RENCTSDCTSECYP3A4 | |
| SCHEMBL5276668 | 0.86 | REN (0.46) | RENCTSDCTSECYP3A4 | |
| SCHEMBL5272190 | 0.86 | REN (0.44) | RENCTSDCTSECYP3A4 | |
| SCHEMBL5274458 | 0.85 | REN (0.42) | RENCTSDCTSECYP3A4 | |
| SCHEMBL5276272 | 0.85 | REN (0.46) | RENCTSDCTSECYP3A4 | |
| SCHEMBL5274727 | 0.85 | REN (0.46) | RENCTSDCTSECYP3A4 | |
| SCHEMBL5276857 | 0.84 | REN (0.45) | RENCTSDCTSECYP3A4 | |
| SCHEMBL5280198 | 0.83 | REN (0.48) | RENCTSDCTSECYP3A4 | |
| SCHEMBL5276771 | 0.83 | REN (0.47) | RENCTSDCTSECYP3A4 | |
| SCHEMBL5272039 | 0.82 | REN (0.41) | RENCTSDCTSECYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1620403-B1 | NOVEL 3,4-DISUBSTITUTED 1,2,3,6-TETRAHYDROPYRIDINE DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2007-11-28 | — | — | EP | claimed |