SCHEMBL5277255

SCHEMBL5277255

CCCn1nnc(Cl)c1Br

nearest known ligand 0.42

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
GRM2 Q14416 2/20 0.42
SLC9A1 P19634 2/20 0.39
ALDH1A1 P00352 3/20 0.39
CYP1A2 P05177 2/20 0.39
TOP2A P11388 1/20 0.37
MEN1 O00255 1/20 0.35
CYP2C9 P11712 1/20 0.35
CYP2C19 P33261 1/20 0.35
KMT2A Q03164 1/20 0.35
GRIA4 P48058 1/20 0.32
HCAR3 P49019 1/20 0.32
CSNK2A2 P19784 1/20 0.30
CSNK2B P67870 1/20 0.30
CSNK2A1 P68400 1/20 0.30
CSNK2A3 Q8NEV1 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5277574 0.88 GRM2 (0.45) GRM2SLC9A1ALDH1A1CYP1A2TOP2A
SCHEMBL5275921 0.85 SLC9A1 (0.45) GRM2SLC9A1ALDH1A1TOP2AHCAR3
SCHEMBL5279001 0.83
SCHEMBL5282659 0.78 GRM2 (0.44) GRM2SLC9A1ALDH1A1CYP1A2TOP2A
SCHEMBL5275766 0.78 SLC9A1 (0.41) GRM2SLC9A1ALDH1A1CYP1A2TOP2A
SCHEMBL5280789 0.77 GRM2 (0.43) GRM2SLC9A1ALDH1A1CYP1A2TOP2A
SCHEMBL5274642 0.77 CYP1A2 (0.43) GRM2SLC9A1ALDH1A1CYP1A2TOP2A
SCHEMBL5274680 0.76 GRM2 (0.40) GRM2SLC9A1ALDH1A1CYP1A2TOP2A
SCHEMBL5274583 0.75 SLC9A1 (0.39) GRM2SLC9A1ALDH1A1CYP1A2TOP2A
SCHEMBL5285294 0.75 SLC9A1 (0.39) GRM2SLC9A1ALDH1A1CYP1A2TOP2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1859781-A2 Brightening and/or colouring agent with triazoles Henkel Kommanditgesellschaft auf Aktien (DE) 2007-11-28 EP disclosed