Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Arecoline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 known ✓ | P08172 | 2/20 | 0.96 |
| ▸ | CHRM3 known ✓ | P20309 | 2/20 | 0.96 |
| ▸ | BLM | P54132 | 1/20 | 1.00 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 1.00 |
| ▸ | LMNA | P02545 | 2/20 | 0.96 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.96 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.96 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.96 |
| ▸ | THRB | P10828 | 1/20 | 0.96 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.59 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.59 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.59 |
| ▸ | THPO | P40225 | 1/20 | 0.59 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.57 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Arecoline SCHEMBL44065 | 0.98 | CHRM2 (1.00) | BLMMCOLN3LMNACHRM2CHRM4 | |
| Arecoline SCHEMBL3057863 | 0.96 | CHRM2 (0.96) | BLMMCOLN3LMNACHRM2CHRM4 | |
| Arecoline SCHEMBL28717437 | 0.92 | CHRM2 (0.87) | BLMMCOLN3LMNACHRM2CHRM4 | |
| Arecoline SCHEMBL28696005 | 0.88 | CHRM2 (0.79) | BLMMCOLN3LMNACHRM2CHRM4 | |
| Arecoline SCHEMBL28727000 | 0.88 | CHRM2 (0.79) | BLMMCOLN3LMNACHRM2CHRM4 | |
| SCHEMBL19077994 | 0.82 | CHRM3 (0.72) | BLMMCOLN3LMNACHRM2CHRM4 | |
| Arecoline SCHEMBL28516815 | 0.82 | CHRM2 (0.69) | BLMMCOLN3LMNACHRM2CHRM4 | |
| Citric Acid SCHEMBL28905687 | 0.82 | LMNA (0.69) | BLMMCOLN3LMNACHRM2CHRM4 | |
| Arecoline SCHEMBL10660986 | 0.81 | CHRM2 (0.68) | BLMMCOLN3LMNACHRM2CHRM4 | |
| Bromide SCHEMBL10920212 | 0.79 | BLM (0.66) | BLMMCOLN3LMNACHRM2CHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 379 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-122042870-A | Method for detecting arecoline residues in biological sample and application of method | 湖南九安禾生物科技有限公司 | 2026-05-15 | — | — | CN | claimed |
| CN-119969632-A | Betel nut flavored product | 深圳市合瑞生物科技有限公司 | 2025-05-13 | — | — | CN | claimed |
| CN-118812418-B | Preparation method of high-purity arecoline hydrobromide | 合肥亿帆生物制药有限公司 | 2025-02-28 | — | — | CN | claimed |
| CN-117107524-B | Canvas and preparation method thereof | 潍坊佳诚数码材料有限公司 | 2025-02-25 | — | — | CN | claimed |
| CN-118812418-A | Preparation method of high-purity arecoline hydrobromide | 合肥亿帆生物制药有限公司 | 2024-10-22 | — | — | CN | claimed |
| CN-118501327-A | Method for identifying betel nuts in Xiaoerkang granules | 海南葫芦娃药业集团股份有限公司 | 2024-08-16 | — | — | CN | claimed |
| CN-118203144-A | Betulin composition and preparation method thereof | 东莞市吉纯生物技术有限公司 | 2024-06-18 | — | — | CN | claimed |
| CN-117929596-A | Fingerprint of freeze-dried powder of standard decoction of Dayuan decoction and construction method thereof | 西安康远晟生物医药科技有限公司 | 2024-04-26 | — | — | CN | claimed |
| CN-114773257-B | Betulin hydrobromide preparation method and solid-liquid continuous extraction coupling device | 长沙绿叶生物科技有限公司 | 2024-03-19 | — | — | CN | claimed |
| CN-117223883-A | Electronic tobacco tar and electronic cigarette | 昌宁德康生物科技（深圳）有限公司 | 2023-12-15 | — | — | CN | claimed |
| WO-2006138012-A1 | P450 SUBSTRATES AND METHODS RELATED THERETO | CERES INC. (US) | 2006-12-28 | — | — | WO | claimed |
| CN-1792173-A | Plant agent for killing snails, prepn. method and use method thereof | UNIV JIANGSU (CN) | 2006-06-28 | — | — | CN | claimed |
| CN-1168446-C | Application of arecaline hydrobromide as medicine for arrhythmia | 夏国瑾 | 2004-09-29 | — | — | CN | claimed |
| CN-1451277-A | Plant source snail killing agent | XIA GUOJIN (CN) | 2003-10-29 | — | — | CN | claimed |
| EP-1328261-A2 | TREATMENT OF NEURODEGENERATIVE DISEASE | Minerva Biotechnologies Corporation (US) | 2003-07-23 | — | — | EP | claimed |
| US-20030060487-A1 | Treatment of neurodegenerative disease | MINERVA BIOTECHNOLOGIES CORPORATION | 2003-03-27 | — | — | US | claimed |
| CN-1398588-A | Application of arecaline hydrobromide as medicine for arrhythmia | XIA GUOJIN (CN) | 2003-02-26 | — | — | CN | claimed |
| WO-2001078709-A2 | TREATMENT OF NEURODEGENERATIVE DISEASE | MINERVA BIOTECHNOLOGIES CORPORATION (US) | 2001-10-25 | — | — | WO | claimed |
| WO-2001017966-A1 | PROCESS FOR THE PREPARATION OF 1-METHYL-3-CARBOMETHOXY-4-(4'-FLUOROPHENYL)-PIPERIDINE | SMITHKLINE BEECHAM P.L.C. (GB) | 2001-03-15 | — | — | WO | claimed |
| US-6132286-A | Preparation of 1,2,5,6-tetra-hydro-3-carboalkoxypridines such as arecoline and salts of 1,2,5,6-tetrahydro-3-carboalkoxypridines and arecoline hydrobromide | BRANTFORD CHEMICALS INC. (CA) | 2000-10-17 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030060487-A1 | Treatment of neurodegenerative disease | HTT, IAPP, APP | CHRM2 3018/4885CHRM3 2621/4885BLM 3623/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.