Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 2/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | PKM | P14618 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1896153 | 0.77 | KDM4E (0.56) | RAB9ANPC1KDM4EALDH1A1LMNA | |
| SCHEMBL1154499 | 0.67 | MAPT (0.42) | RAB9ANPC1KDM4ELMNATP53 | |
| SCHEMBL973674 | 0.66 | CYP2A6 (0.50) | RAB9ANPC1CYP19A1KDM4EALDH1A1 | |
| SCHEMBL1896855 | 0.63 | IDO1 (0.43) | RAB9ANPC1CYP19A1KDM4EALDH1A1 | |
| SCHEMBL8096488 | 0.62 | KDM4E (0.36) | RAB9ANPC1CYP19A1KDM4EALDH1A1 | |
| SCHEMBL2407790 | 0.61 | CYP1A2 (0.51) | RAB9ANPC1CYP19A1KDM4EALDH1A1 | |
| SCHEMBL171853 | 0.61 | HDAC8 (0.47) | RAB9ANPC1KDM4EALDH1A1LMNA | |
| SCHEMBL1802657 | 0.60 | CYP1A2 (0.38) | RAB9ANPC1CYP19A1KDM4EALDH1A1 | |
| SCHEMBL8836004 | 0.60 | ENPP3 (0.45) | RAB9ANPC1KDM4EALDH1A1TP53 | |
| SCHEMBL4390652 | 0.59 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1863797-A1 | 2-AZETIDINYL-4-(lH-PYRAZOL-3-YLAMINO)PYRIMIDINES AS INHIBITORS OF INSULIN-LIKE GROWTH FACTOR-I RECEPTOR ACTIVITY | AstraZeneca AB (SE) | 2007-12-12 | — | — | EP | disclosed |
| WO-2006100461-A1 | 2-AZETIDINYL-4-(lH-PYRAZOL-3-YLAMINO)PYRIMIDINES AS INHIBITORS OF INSULIN-LIKE GROWTH FACTOR-I RECEPTOR ACTIVITY | ASTRAZENECA AB (SE) | 2006-09-28 | — | — | WO | disclosed |