Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 11/20 | 0.67 |
| ▸ | MAPK14 | Q16539 | 9/20 | 0.67 |
| ▸ | METAP1 | P53582 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.41 |
| ▸ | ABL2 | P42684 | 1/20 | 0.41 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.41 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.41 |
| ▸ | MAP3K20 | Q9NYL2 | 1/20 | 0.41 |
| ▸ | AURKA | O14965 | 2/20 | 0.39 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.38 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2045872 | 0.95 | TGFBR1 (0.68) | TGFBR1MAPK14METAP1THRBTGFBR2 | |
| SCHEMBL5188286 | 0.84 | TGFBR1 (0.70) | TGFBR1MAPK14THRBTGFBR2ABL2 | |
| SCHEMBL2045365 | 0.83 | TGFBR1 (0.76) | TGFBR1MAPK14METAP1THRBTGFBR2 | |
| SCHEMBL5186721 | 0.83 | TGFBR1 (0.60) | TGFBR1MAPK14THRBTGFBR2ABL2 | |
| SCHEMBL5187792 | 0.83 | TGFBR1 (0.60) | TGFBR1MAPK14THRBTGFBR2ABL2 | |
| SCHEMBL5091553 | 0.82 | TGFBR1 (0.71) | TGFBR1MAPK14THRBTGFBR2ABL2 | |
| SCHEMBL2050975 | 0.82 | TGFBR1 (0.71) | TGFBR1MAPK14THRBTGFBR2ABL2 | |
| SCHEMBL5186629 | 0.81 | TGFBR1 (0.69) | TGFBR1MAPK14THRBTGFBR2ABL2 | |
| SCHEMBL5186668 | 0.81 | TGFBR1 (0.66) | TGFBR1MAPK14THRBTGFBR2ABL2 | |
| SCHEMBL373455 | 0.80 | TGFBR1 (1.00) | TGFBR1MAPK14THRBTGFBR2ABL2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1804801-A2 | METHODS OF TREATING VASCULAR INJURIES | Biogen Idec MA, Inc. (US) | 2007-07-11 | — | — | EP | claimed |
| WO-2006044509-A2 | METHODS OF TREATING VASCULAR INJURIES | BIOGEN IDEC MA INC. (US) | 2006-04-27 | — | — | WO | claimed |